... of Translational Medicine 2010, 8:19http://www.translational-medicine.com/content/8/1/19Page 6 of 9 in the understanding of melanoma biology haveresulted in the discover y of other promising ... 0.035).Conclusions: Increased shedding of HU177 in the serum of primary melanoma patients is associated with poorprognosis. Further studies are warranted to determine the clinical utility of HU177 in risk ... studydesign and interpretation of results. IO served as the principal investigatorfor the project, overseeing the study design, analysis of data, interpretation of results, and writing of the manuscript....