... of Translational Medicine 2010, 8:19 http://www.translational-medicine.com/content/8/1/19 Page 6 of 9 in the understanding of melanoma biology have resulted in the discover y of other promising ... 0.035). Conclusions: Increased shedding of HU177 in the serum of primary melanoma patients is associated with poor prognosis. Further studies are warranted to determine the clin...
Ngày tải lên: 18/06/2014, 16:20
... expression of Oct4 or Sox2 Positive staining for Oct4 and Sox2, mainly localized in the nucleus, were observed in the cancer cells of tumor tissues (Fig. 1). The distribution of immunostaining scores ... ession of Oct4 and Sox2. Immunohistochemical s taining for Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma. Brown grains represent a positive signal (3, 3-dia...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " The responsiveness of the uterine fibroid symptom and health-related quality of life questionnaire (UFS-QOL)" doc
... remains in tact is needed to address this limitation. Patient-reported outcomes of symptom severity and HRQL are becoming increasingly important for evaluating treatment of uterine fibroids within ... clinical setting. With the increasing availability of noninvasive therapies to hysterectomy, it will be especially important to assess symptom reduction of uterine fibroids and evalu...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte " ppt
... and the presence of many inflamma- tory mediators, including cytokines, chemokines and complement proteins have been only identified in the post-mortem AD brain in the vicinity of senile plaques and ... pathology within the brain, as inflammatory cytokine expression and other markers of inflammation are pronounced in individuals with AD pathology. The current study examines whet...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo khoa học: The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides pot
... of sequence-independent artefacts, most of which are attrib- utable to their ability to bind a number of heparin-binding proteins [28]. In our search for allele-speci®c inhibitors based on single- nucleotide ... vast amounts of active enzyme. Reviews discussing PS-ODN-mediated inhibition of gene expression warn against erroneous interpretation of r esults caused by the protein-b...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo khoa học: Possible involvement of an FKBP family member protein from a psychrotrophic bacterium Shewanella sp. SIB1 in cold-adaptation potx
... °C. Determination of the N-terminal amino acid sequence, fol- lowed by the cloning and sequencing of the gene encoding this protein, revealed that this protein is a member of the FKBP family of proteins ... thereby preventing aggregation and assisting in proper folding [2]. The other class of proteins includes enzymes that catalyze specific steps of protein folding. This group o...
Ngày tải lên: 16/03/2014, 16:20
Báo cáo khoa học: Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein docx
... protein kinase isoform involved in the s ignalling pathway downstream of muscarinic m3 receptors in SK-N-BE(C) neuroblasto ma cells [15]. The Ó FEBS 2004 Differential role of PKC isoforms in APP ... of sAPPa release [9] (Fig. 5) suggesting that the defective i soform was not involved in the receptor-mediated activation of APP processing. Treatment of SYDe with increasing co...
Ngày tải lên: 23/03/2014, 13:20
báo cáo hóa học:" Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines" pptx
... evalua- tion of dasatinib in clinical trials in melanoma patients. Two clinical trials of dasatinib in melanoma are currently underway, including a phase I/II study of dasatinib in combination with dacarbazine ... Effect of imatinib on proliferation). Dasatinib in combination with chemotherapy The effect of dasatinib in combination with chemother- apy was examined...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Adjuvant therapy of melanoma with interferon: lessons of the past decade" pot
... Trend in a single patient; (B) trend of the average value of Treg cells during HDI IV treatment; (C) Boxplot summarizing the data observed in the cohort of patients during the initial 4 weeks of ... test new combinations with HDI in the advanced and adjuvant disease settings, start- ing with recent immunological findings. This will include use of neoadjuvant approaches, o...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Molecular Etiology of Hearing Impairment in Inner Mongolia: mutations in SLC26A4 gene and relevant phenotype analysis" ppt
... patient's clinical history including infection, possible head or brain injury and the usage of aminoglycoside antibiotics. In addition, 50 (race matched) controls with normal hearing were screened ... review of the role of neonatal hearing screening in the detection of congenital hearing impairment. Health Tech- nol Assess 1997, 1(10):1-176. 2. Brody JE: Personal Health;...
Ngày tải lên: 18/06/2014, 15:20