... (1.25-5.68) respectively. Interestingly, an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of thymosin α-1 in this meta-analysis ... E, Marinelli M, Tambussi G, Finazzi R et al. Hepatitis B surface antigen clearance and appearance of antibodies against hepatitis B surface after treatment with recombinant inter...
Ngày tải lên: 02/11/2012, 11:17
... is a recombinant protein comprising IL-2 fused with the alpha chain of diphtheria toxin, (DAB389+IL-2), capable of transiently eliminating T regs. Phase II/III clinical trials, involving stage ... Baseline and reduction of blood PSA levels for patients who showed partial clinical responses following vaccination with the vaccination time point. Patient PSA baseline levels (μg/L) Vaccination t...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis" pot
... controls. Plasma vitamin D binding protein in critically ill subjects with sepsis, critically ill subjects without sepsis and healthy sub-jectsFigure 2 Plasma vitamin D binding protein in critically ... creati- nine; DBP: is vitamin D binding protein; DIC: is disseminated intravascular coagulation; ELISA: is Enzyme-Linked ImmunoSorbent Assay; HIV: is human Immunodeficiency Virus; ICU: i...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... participated in the in vitro studies. JG participated in the in vitro studies. IM participated in the in vivo studies. RA participated in the PCR studies. VS participated in the in vivo studies. ... high killing potential in ovarian cancer cell lines and a signifi- cant tumor growth inhibition in animals, indicating that the DTA-H19 construct has a high therapeutic poten...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: " Zinc in innate and adaptive tumor immunity" pot
... proteins, including sig- naling enzymes and transcription factors. Zinc is required for the activity of more than 300 enzymes, interacting with zinc-binding domains such as zinc fin- gers, RING fingers, ... domains [12-14]. The RING finger domain is a zinc finger which contains a Cys3HisCys4 amino acid motif, binding two zincs, con- tains from 40 to 60 amino acids. RING is an acronym specifyi...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... Kanamycine resistance gene (insert 812 bp), using BstEII and Hind III restriction sites, resulting in the expression vector P4-Luc. T he DTA c ontaining vector P4-DTA was designed by replacing the ... within the cells and in consequence triggering their necrosis. Finally, we dealt with the question whether transfec- tion of both single promoter vectors (expressing the diphtheria toxin) i...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " Reduction in patient burdens with graphical computerized adaptive testing on the ADL scale: tool development and simulation" doc
... as "the thing we normally do in daily living including any daily activity we perform for self-care (such as feeding ourselves, bathing, dressing, grooming), work, homemak- ing, and leisure." ... assessing appraisals. With the networking and rapidly growing mobile point of care development in hos- pitals, IRT-based assessing appraisal is more in line with real-world test, espec...
Ngày tải lên: 18/06/2014, 18:20
báo cáo hóa học: " Change in patient concerns following total knee arthroplasty described with the International Classification of Functioning, Disability and Health: a repeated measures design" docx
... 4 Week 6 Decreasing pain in your surgical knee 6 (5–7) † 7 (6–7) 6 (5–7) 6 (4–6) Reducing the swelling in your surgical leg 3 (1–6) 6 (5–7) 6 (5–7) 5 (3–6) Avoiding infection in your surgical ... Poole RM: Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 2001, 94:149-158. 17. Roos EM, Toksvig-Larsen S: Knee injury and...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " Changes in quality of life among Norwegian school children: a six-month follow-up study" doc
... Rehabilita- tion (in German) (Quality of life in cronical ill children during inpatient rehabilitation). In Verbindung und Veränderung im Fokus der Medizinischen Psychologie (Connections and changes in medical ... psychological interventions [26] for children typically being conducted within a relative short time frame. In a longitudinal study, Shek and col- leagues [27,28] examined...
Ngày tải lên: 18/06/2014, 19:20
Báo cáo hóa học: " Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)" pptx
... noninvasive brain stimula- tion (NBS) techniques that can alter indices of brain excit- ability, a lasting functional benefit from these interventions in clinical populations remains elusive. Ini- tially ... electro-convulsive therapy (ECT), there is increasing interest in how neuromodulation by noninvasive brain stimulation (NBS) might be extended to neurological disorders. Underpinning...
Ngày tải lên: 19/06/2014, 08:20