báo cáo hóa học:" Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer" ppt

... The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence Yunpeng Feng*, Xiuli Wang*, Liang Xu, Hong Pan, Shan Zhu, Qian Liang, ... extraction and real-time quantitative PCR Total cellular RNA was extracted from the 293T cells according to the Promega Total RNA Isolation System man- ual. RN...

Ngày tải lên: 07/03/2014, 02:20

... charac- teristics resemble those of the natural aging process in humans and other animals. As the inner ear tissue is unacquirable during life in humans, and the genetic and environmental background ... increased mutation load in the inner ear. In our study, increases in TFAM expression and dele- tion mutation load were demonstrated in the inner ear...

Ngày tải lên: 14/03/2014, 23:20

... primer, 5¢-CAAAACCGAACAAA AGCGAAACGCCA-3¢,5¢ primer, 5¢-CAACCCATCCAA ATCCAGACAAAAT-3¢. All constructs were confirmed by sequencing. The p21 (Waf1 ⁄ Cip1) promoter luciferase con- struct has been described ... ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1, 193–199. 17 Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K & Nakayama K...

Ngày tải lên: 23/03/2014, 07:20

... essential for transcriptional activation of the human NOX4 promoter Figure 1 shows the alignment of the 5¢-flanking and 5¢-noncoding sequences of the human, rat and mouse NOX4 genes. Compared with the ... similarity between the rat and mouse sequences, the similarity of the human sequence was relatively low. Therefore, we isolated the promoter region o...

Ngày tải lên: 29/03/2014, 00:20

... reproduc- tion in any medium, provided the original work is properly cited. Research Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy ... an increase of Epidermal Growth factor Receptor (EGFR) Gene Copy Number (GCN). Aim of this study was to assess the role of EGFR-GCN in a...

Ngày tải lên: 18/06/2014, 16:20

... also activate CD14-dependent innate immune response in macrophages. While none of these data point to CD14 or innate immune response as etiological in neurodegenera- tive disorders, these findings from in ... A2, each of which are potent activators of a large family of G protein-coupled receptors [5]. The combination of these initial and secondary signaling cas...

Ngày tải lên: 19/06/2014, 22:20

... 1 of 8 (page number not for citation purposes) Journal of Neuroinflammation Open Access Research Platelet-activating factor enhancement of calcium influx and interleukin-6 expression, but not ... In brief, human embryonic brain tissues were dissected into small blocks, incubated in phosphate-buffered saline (PBS) containing 0.25% trypsin and 40 µg/ml DNase...

Ngày tải lên: 19/06/2014, 22:20

... transmigration of monocytes and macrophages across the BBB to the sites of axonal injury in the brain [33,37]. Both in vitro and in vivo findings suggest that hypoxia/ischemia-induced infiltra- tion of monocytes ... HIF-1-binding sites in the pro- moter regions of MCP-1 and MCP-5 genes. Hypoxia and CoCl 2 up-regulate the expression of both HIF-1α and...

Ngày tải lên: 19/06/2014, 22:20

... histopathology Hematoxylin and Eosin staining was performed. Double Immunostaining was used to detect astrocytes and T-cells. In brief, sections were washed in PBS, followed by rinsing in PBS-0.5% Triton ... findings point to IRF7 as a key signaling intermediate in modulation of autoimmune demyelinating disease, and open the possibility that innate signals may also be protectiv...

Ngày tải lên: 19/06/2014, 22:20

... contributing to 1 Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway Leonid Tarassishin*, Hyeon-Sook Suh, and Sunhee ... versions will be made available soon. Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt p...

Ngày tải lên: 19/06/2014, 22:20

... al.: Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer. Journal of Ovarian Research ... 12 RESEA R C H Open Access Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and...

Ngày tải lên: 20/06/2014, 07:20

... LS and SLS estimators is independent of κ. The channel will be no fading or AWGN when κ →∞. 6.5. Substantial Benefits of the Rician Fading MIMO Channels. In Tables 3 and 4, substantial benefits of ... 2010, Article ID 753637, 14 pages doi:10.1155/2010/753637 Research Article Appropriate Algorithms for Estimat i ngFrequency-Selective Rician Fading M...

Ngày tải lên: 21/06/2014, 11:20

... designed from an internal LKNKHFQYTYDNGWKYEFHV) and P2 (a reverse primer designed from an internal AFSQGHWEHPEQAHGDKRED), and nested PCR was done with P1 and P3 (a reverse primer designed from an ... suggested that an endogenous amino thiol-like compound with a molecular weight greater than Mr 1,400 was responsible for the activation. Keywords: phenolic acid decarb...

Ngày tải lên: 21/06/2014, 17:20

... OFDM System and Its Application to Frame Synchronization in OFDM Mode of WMAN Ch. Nanda Kishore and V. U. Reddy Hellosoft India Pvt Ltd., 8-2-703, Road no. 12, Banjara Hills, Hyderabad 500 034, India Received ... scheme for transmitting data at very high rates over time dispersive radio channels. In an OFDM system, frame synchronization and frequency offset es...

Ngày tải lên: 22/06/2014, 22:20

... 11:19 http://www.biomedcentral.com/1471-2229/11/19 Page 8 of 10 RESEARCH ARTICLE Open Access The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis Hatem ... Kataoka T, Watanabe-Takahashi A, Hayashi N, Ohnishi M, Mimura T, Buchner P, Hawkesford MJ, Yamaya T, Takahashi H: V...

Ngày tải lên: 11/08/2014, 11:21