... AccessResearchPPARα downregulates airway inflammation induced by lipopolysaccharide in the mouseCarine Delayre-Orthez1, Julien Becker1, Isabelle Guenon2, Vincent Lagente2, Johan Auwerx3, Nelly Frossard1 ... chemokineexpression by lipopolysaccharide in vitro and in vivo. JImmunol 1999, 163:1537-1544.6. Goodman RB, Pugin J, Lee JS, Matthay MA: Cytokine-mediated inflammation in acute lung injury. Cytokine ... sug-gesting that PPARα may also play a beneficial role in tissue remodeling [24,25].We have here investigated the role of PPARα in a mousemodel of LPS -induced airway inflammation characterizedby...