... These surprising findings suggest that TCF4 might be the main binding partner for b-catenin during development and progression of colorectal cancer whereas an enhancement of Wnt/b- catenin transcriptional ... accompanied by a shift of b-catenin binding partners from TCF4 to LEF1 and we therefore expected to find TCF4 positivity mainly in central tumour areas and LEF-1 mainly in the...
Ngày tải lên: 18/06/2014, 16:20
... four level scale (0 = no staining, 1 = weak staining, 2 = moderate staining, 3 = intense staining) by a GU patholo- gist. Results Expression Profiling of Ovarian Cancer Patients We sought to ... Interestingly, a recent study in ovarian cancer cells reported that overex- pression of Aurora-A could increase cell survival in the presence of paclitaxel [37]. Through microarray pro...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học: " Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS)" pdf
... to 53% in those with both cough and wheeze [4]. In epidemiologic studies, more than 50% of patients with COPD complained of difficulty maintaining and initiating sleep, and 25% complained of excessive ... of the research study, includ- ing developing protocols; site coordination; data collec- tion; data oversight; and reporting of data. DMM managed the UK portion of the resear...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " Interferon-β1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis" pptx
... increase in plasma CD31+EMP level. There was insufficient data for statistical analysis of these findings. Discussion We have observed a decrease in plasma CD31+EMP fol- lowing initiation of intramuscular ... presence of continuing low-level damage to the BBB, at least to the endothelial component of the BBB [10]. Several lines of evidence support the essential role of the bre...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt
... proteins PSA or PSMA were evident in 5 patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin. Given the var- iation in band intensity ... of urine (for at least 18 hours at 37°C) (Figure 6c). Discussion We present the findings of a pilot study, investigating uri- nary exosomes in prostate cancer patients. We...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học: " Can we derive an ''''exchange rate'''' between descriptive and preference-based outcome measures for stroke? Results from the transfer to utility (TTU) technique" doc
... improvements in predictive validity that we were able to obtain by deriving separate transformations for clinically distinct subgroups of patients. Finally, our findings suggest that validity in predicting ... descriptive measures of health-related quality of life (HRQoL) are unsuitable for informing decision-makers of the broader consequences of increasing or decreasing funding...
Ngày tải lên: 18/06/2014, 18:20
Báo cáo y học: " A retrospective quality assessment of pre-hospital emergency medical documentation in motor vehicle accidents in south-eastern Norway"
... the mechanism of injury for all patients. According to local procedures and international Utstein Guidelines, key variables important in determining mechanism of injury (MOI) in MVA patients include ... analysis, and in the revising and final approval of the manuscript. Competing interests TS is a research fellow in the Norwegian Air Ambulance Foundation. SS has no competing fin...
Ngày tải lên: 25/10/2012, 09:56
báo cáo hóa học:"Fuzzy Hyers-Ulam stability of an additive functional equation" pptx
... there exists a mapping A : X → Y satisfying the following: (1) A is a fixed point of J, that is, A x 2 = A(x) 2 (2.6) for all x ∈ X. The mapping A is a unique fixed point of J in the set Ω = {h ... there exists a mapping A : X → Y satisfying the following: (1) A is a fixed point of J, that is, 2A(x) = A(2x) (2.8) for all x ∈ X. The mapping A is a unique fixed point of J in the set...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:"On quotients and differences of hypergeometric functions" pptx
... below). For information about publishing your research in Journal of Inequalities and Applications go to http://www.journalofinequalitiesandapplications.com/authors/instructions/ For information ... −1) of Lemma 2.11 is equivalent to the condition 1/c + 1/d ≤ 2 of Theorem 3.6. 4.8. Proof of Theorem 3.7. (1) The left-hand side of this inequality is a direct consequence of part...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx
... receptor; (IGFBP-3): Insulin-like Growth Factor Binding Protein-3; (IGFBP-4): Insulin-like Growth Factor Binding; Protein-4; (MAPK): Mitogen-activated protein kinase; (IMCG): Interdisciplinary Melanoma Cooperative ... purposes) Journal of Translational Medicine Open Access Research Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and se...
Ngày tải lên: 18/06/2014, 15:20