báo cáo hóa học:" ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function" pptx
báo cáo hóa học:" Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood " pot
... Translational MedicineOpen AccessResearch Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood monocytes (PBMC) of hepatitis C patients during the first ... relapsed by the end of treatment. Changes in Global Gene Expression Gene expression in PBMC changed dramatically and rap-idly during PEG-interferon- α2b (PegIntron™) /ribavirin therapy, with major changes ... 7.5 8.0 8.4 interferon -induced protein 44-likeIFIH1 3.3 2.0 3.3 2.4 2.1 2.3 2.2 interferon induced with helicase C domain 1IFIT1 12.2 4.1 9.9 6.0 4.8 5.6 4.8 interferon -induced protein with tetratricopeptide...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... hepatic cancer, colon cancer and lung cancer. Immunostaining of prostate cancer tissue with antibodies against AMACR and PSAFigure 2Immunostaining of prostate cancer tissue with antibodies against ... mRNA in prostate cancer line LNCaP, but only very weak expression of AMACR mRNA was observed in normal adult liver and pancreas (Figure 1A) . In contrast, the AMACR mRNA levelwas elevated in all ... AbstractAlpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. High expression levels of...
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Báo cáo hóa học: "Genomic aberrations in borderline ovarian tumors" doc
... tumorcalculated in the present series was 18.72. It is interest-ing to note that for the bilateral borderline ovarian tumors the ANCA index was 24.5 whereas for the uni-lateral borderline ovarian tumors ... rominently in both overt carcinomas[37,50] and in the present series (the gains were found in 5 of 5 cases with bilateral borderl ine tumors and in 4of 6 informative unilateral tumors showing ... cytogenetic abnormal-ities occurring in ovarian carcinomas and tumors of borderline malignancy could provide insights into theirpathogenetic relatio nship, little information is availableon the...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... capable of phagocytosing myelin and damaging axons. In this study, wecharacterize the regional, temporal and cellular expression of CCR1, CCR2 and CCR5 mRNA in the spinal cord of ratswith myelin ... inflammatoryactivity and demyelination, as previously described byBrück et al [36].Distribution of CCR1, CCR2 and CCR5 mRNA in the rat spinal cordNo expression of CCR1, CCR2 or CCR5 was detectedwithin the ... receptors and their ligands.Here we present data from a series of experiments whichwas designed to characterize the expression of CC chem-okine receptors CCR1, CCR2 and CCR5 in the spinal cordof...
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báo cáo hóa học: " Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)" pptx
... soon. Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)Journal of Neuroinflammation 2 012 , 9 :1 doi :10 .11 86 /17 42-2094-9 -1 Pascal ... transformation in mouse and human. J Clin Invest 2 011 , 12 1 :14 56 -14 70. 37. Spits H, Di Santo JP: The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. ... NCR1 is involved in the formation of these inclusions remains to be fully determined. In order to further validate our findings, we analysed NCR1 expression in U2 51 cells. This confirmed expression...
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báo cáo hóa học:" Differential expression of type X collagen in a mechanically active 3-D chondrocyte culture system: a quantitative study" docx
... real-time quantification RT-PCR detection of type X collagen mRNAGene Primer Sequence Type X collagen Forward 5'-AGTGCTGTCATTGATCTCATGGA-3'Reverse 5'-TCAGAGGAATAGAGACCATTGGATT-3'18S ... Orthopaedic Surgery and ResearchOpen AccessResearch article Differential expression of type X collagen in a mechanically active 3-D chondrocyte culture system: a quantitative studyXu Yang†, Peter ... results in an increase of Col X mRNA expression. Such quantitative analysis hasimportant implications for our understanding of mechanosensitivity of cartilage and mechanicalregulation of chondrocyte...
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Báo cáo hóa học: " Transient expression of homologous hairpin RNA interferes with PVY transmission by aphids" docx
... that transient expression of anantiviral hairpin RNA by A. tumefaciens results in resist-ance to PVY transmission by aphids. Several studies haveDetection of PVY CP and PVY small interfering RNAs ... PVY transmission exhib-ited by transiently expressed IRCPPVY could reflect anykind of unspecific, defence response of plants elicited by hairpin RNA sequences that could somehow block the transmission ... Interference with PVY transmission by Agrobacterium tumefaciens-mediated transient expression of IRCPPVY.AgroinfiltratedaExperiments TotalbPercentage transmission Empty vector 2 16/16 100pIRCPPVY...
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báo cáo hóa học:" ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function" pptx
... ResearchOpen AccessResearch ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and functionDaniel R Christie1, Faheem M Shaikh2, ... a change in receptorconformation, by masking functional domains within the integrin heterodimer, by affecting integrin interactionwith other membrane bound proteins or glycolipids, or by another, ... enzyme in ovarian cancer. The accumulating evidence indicatingthat ST6Gal-I- mediated integrin sialylation causesincreased cell migration and invasion in multiple tumortypes suggests that ST6Gal-I...
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báo cáo hóa học:" CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion" pdf
... CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-depen-dent and FAK-independent fashion Journal of Ovarian Research 2010, 3:15Received: ... and reproduction in any medium, provided the original work is properly cited.Research CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in ... resistance to chemotherapyby inactivating apoptotic factors and enhancing survival pathways that antagonize apoptotic signals [2]. The first-line chemotherapeutic agent for OvCa is cisplatin....
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báo cáo hóa học:" Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors" docx
... localization of ALDH1 in normal ovaries. [A-B] Intens e staining of numerous cells of stroma (S) and surfaceepithelial cells (SE) was observed in normal ovary. Insets showing examples of ALDH1 stained ... apoptosis in various celltypes including ovary [12-17]. In ovarian cancer the expression of the retinol binding proteins involved in RA metabolism is reduced [18]. Also it was shown that in the intestine ... In additio n, staining of the surfaceepithelium was patchy compared to normal ovary (Fig-ure 3A) and contained areas of intense staining adjacentto areas of no staining (Figure 4D - 4F).In...
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báo cáo hóa học:" HOX genes in ovarian cancer" pot
... suggesting b1integrinhasaroleinmediatingthese changes. Intriguingly, these changes in proteinlevel are not reflected at the RNA level, indicating thatthe effect of HOXA4 on b1 integrin and ... [17-20].Function of HOX genes in ovarian cancerTumour Growth In addition to phenotypic determination, HOX genes arethought to play a role in the oncogenesis of ovarian can-cer. HOXB7 overexpression in immortalised ... 16 HOX genes in ovarian cancer cell lines were found, the most com-mon being HOXB7, HOXA13 and HOXB13. Overexpres-sion varied between cell lines but of these 16 genes, Figure 1 Role of HOX genes...
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báo cáo hóa học:" Respiratory symptoms in adults are related to impaired quality of life, regardless of asthma and COPD: results from the European community respiratory health survey" docx
... suffers from one or more respiratory symptoms [4,5]. Respiratory symptoms are important markers of the risk of having or developing disease. Respiratory symptoms have been shown to be predictors ... respiratory symptoms are important determinants of reduced health related quality of life (HRQoL)[12-15]. The prevalence of respiratory symptoms exceeds the combined prevalences of asthma and COPD, ... Health and Quality of Life Outcomes 2010, 8:107http://www.hqlo.com/content/8/1/107Page 4 of 8RESEARC H Open Access Respiratory symptoms in adults are related to impaired quality of life, regardless...
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Báo cáo hóa học: " Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment" pptx
... (H31 0A) antibody of diff erent tissue specimens.At×40magnification, (a) human pancreas cancer with strong staining, (b) human pancreas cancer with moderate staining, (c) human pancreas cancer with ... ORIGINAL RESEARCH Open Access Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody FragmentMark D Girgis1,3, Tove Olafsen2, Vania Kenanova2, Katelyn E McCabe2, Anna ... tumor targeting and shows promise as an imaging and potentially the rapeutic agent.Keywords: imaging, pancreas cancer, CEA, antibody IntroductionPancreatic cancer is one of the most lethal cancers...
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