... contributed in the experimental procedures and in the interpretation of the data, SXW, XL, TFL and WBX gave advises on the work and helped in the interpretation of the data, KTY supervised all the work ... higher incidence of invasion and metastasis at the time of presen- tation to the first biopsy. Therefore, chemotherapy treat- ment is a necessary ancillary method...
Ngày tải lên: 18/06/2014, 15:20
... obtained on the 18 th hour of incubation of monolayer- and 3D-spheroid-cultured CT26 cells. For both culture conditions, the concentration of VEGF was expressed as a function of the total number Journal ... over-expression of this integrin enhanced the adhe- sion of CT26 to ICAM-1-expressing angiogenic hepatic myofibroblasts and endothelial cells; and endowed CT26 cells w...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx
... accordance with both the provisions of the Declaration of Helsinki and Good Clinical Practice. Site monitoring included review of the accuracy of the data in the case report forms. Journal of Translational ... measured by the induction of immune activation in peripheral blood and at the tumor site in a pilot group of patients. The dose of 4 mg/m 2 was chosen f...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... in the NOD mouse model, as well as in other murine mo dels of T1D [95-100]. The feasibility of translating these therapies to humans remai ns to be assess ed. One potential limitation of the ... explore the role of the Treg/IL-2 axis in the patho- physiology of organ-specific autoimmune disorders such as T1 D the functional potential of IL-2 and its possible implicat...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... understanding of the mechanism of action of DNA vaccination. A key observation from many studies to date is that interchan- ging the order of vectors utilized in these regimens has a dramatic impact on the ... stimulatio n sheds light on the mechanism of action of DNA vaccines and their potency as priming agents in terms of: i) the importance of extended yet reduced l...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " How do medical students value health on the EQ-5D? Evaluation of hypothetical health states compared to the general population" ppt
... experience of illness in others than close family. No experience with own illness or illness of others reported 13.7% of the sample. About one quarter of the participants were smokers (Table 1). The ... (degree or professional qualification): 30.9%; per- sonal communication with Dr. Hinz 17.04.08). For the comparison of the valuation of hypothetical health states we used...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells" pot
... drafted the manuscript. VSC participated in the performance of the in vivo viral infections and the isolation of CNS cells. MM participated in the preparation of viral stocks and determination of ... and replicate within them, generating genomic DNA within the cytoplasm of each cell type. These viral DNA motifs are then recognized by DAI, leading to the activa- tion o...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học:" An intron 9 containing splice variant of PAX2" pptx
... electrophoresis of the PAX2 exon 10 RT-PCR products from the mRNA of the lymphoma cell lines. All lymphoma cell lines: band of 339 bp of varying intensity. KM-H2, EHEB, L540 and DG75: band of the expected ... cell lines, 7 of the 9 colon carcinoma cell lines and 1 of the 7 renal carcinoma cell lines expressed the intron 9 and exon 10 containing splice variant. Th...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures" potx
... to the uterus [24]. Therefore, based on the experience of our research group in the identification, and character- ization of potential sources of adult stem cells [7,10,12- 15], the aim of this ... and showed the ability to differentiate into cell types of the three germ layers [17-23]. The human fallopian tubes (hFTs) share the same embry- ologic origin as the ut...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment" pot
... properties. Andro is reported to react with the SH group of cysteine 62 on the p50 subunit of the NF-κB, which blocks the bind- ing of NF-κB to the promoters of their target genes, pre- venting NF-κB ... analysis. The protein level of GLUT4 in the soleus muscles of diabetic mice was only 49.5% that of the non- diabetic mice (Fig. 4; p < 0.05 compared with norm...
Ngày tải lên: 18/06/2014, 15:20