báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" pot

... new osteosarcoma treatments. The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within aheterogeneous tumor there is a small subpopulation ofcells called cancer stem cells (CSCs)” ... Open Access Targeting the osteosarcoma cancer stem cellValerie A Siclari, Ling Qin*Abstract Osteosarcoma is the m ost common type of solid bone cancer and the second leading cause of cancer- relateddeath ... to cancer therapies [15]. Therefore,although treatment with chemotherapy or radiation mayreduce the bulk of the tumor, it may actually miss the most important cell to target, the cancer stem...

báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" ppt

... 10and therefore, there is a great need for developing new osteosarcoma treatments. The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within aheterogeneous tumor there ... Open Access Targeting the osteosarcoma cancer stem cellValerie A Siclari, Ling Qin*Abstract Osteosarcoma is the m ost common type of solid bone cancer and the second leading cause of cancer- relateddeath ... Nielsen-Preiss SM: Cancer stem cells: Seeds of growth in osteosarcoma. Cancer Biol Ther 2009, 8.doi:10.1186/1749-799X-5-78Cite this article as: Siclari and Qin: Targeting the osteosarcoma cancer stem cell....

Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx

... interferon-b)join-ing the RIG-I/MDA5 pathway. In the other pathway,TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1. Thesekinases stimulate IFN-c synthesis via the transcriptionfactor ... the inadequacy of the actual therapy, the chemo-prevention targeting the microenvironment.HCC epidemiologyHepatocellular carcinoma (HCC) accounts for > 5% of allhuman cancers and for 80% ... in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role ofinflammation in carcinogenesis, the clinical impact of HCC and the inadequacy...

báo cáo hóa học:" Targeting the hotspots: investigating spatial and demographic variations in HIV infection in small communities in South Africa" pot

... ratio is computed for the alter-native hypothesis that there is an increased risk of dis-easeinsidethecircle,againstthenullhypothesisthat the risk inside the circle is the same a s that outside. ... observednumber of cases within the window , and E[c] is the cov-ariate adjusted expected number of cases within the window under the null hypothesis. Since the analysis isconditioned on the total number ... expected under the null-hypothesis, and 0 otherwise.For a given zone (circular window), the methodologycalculates the probability of a data point being a c aseinside or outside the circle under...

báo cáo hóa học:" Announcing the Tumor Immunology and Biological Cancer Therapy section (edited by iSBTc) of the Journal of Translational Medicine" ppt

... Immunology and Biological Can-cer Therapy (edited by iSBTc)Bernard A. Fox, PhDPresidentInternational Society for Biological Therapy of Cancer AcknowledgementsFrom the iSBTc Executive Office, Chloé ... charge"BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime."Sir Paul Nurse, Cancer Research UKYour research ... Surinak monitors and supports the subsection interactions with the iSBTc leadership, its membership and BioMed Central; Tara Withington as Executive Director of the iSBTc pro-vides executive...

Báo cáo hóa học: " Introducing the Cancer Microenvironment Section of Journal of Translational Medicine" pot

... lev-els. In contrast, there is a lot to be done with respect totranslating the insights gained in the laboratory on the involvement of the TME in cancer pathogenesis to the clinic and the biomedical ... targets from the cancer microenvironment The "Seed and Soil" theory, proposed by Stephen Pagetover 120 years ago (1889) [1], laid the foundations for the modern concept of the tumor ... that allow the characterization of the molecular profile of non -cancer cells in the TME and oftheir soluble products, and how these cells can be regu-lated at different stages of cancer progression.2)...

báo cáo hóa học:" Osteoblastoma-like Osteosarcoma of the Cuboid: A Case Report" potx

... [3]. Osteosarcoma of the long bo nes, how-ever, is usually diagnosed within months of the symp-tom onset [2]. Lastly, osteosarcomas of the footgenerally are lower grade than the typical osteosarcoma affecting ... variant of osteosarcoma aris-ing in the cuboid bone which, to the best of ourknowledge, is the first published case. This repo rt high-lights the importance of tissue biopsy in the evaluationof ... thoroughly curette the lesion and pack the defectwith cement, which would stabilize the lateral columnand be adequate therapy for a benign lesion. If, however, the histologic analysis of the additional...

báo cáo hóa học:" Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB" doc

... Morrison SJ: Applying the principles of stem- cell biology to cancer. Nat Rev Cancer 2003, 3:895-902.7. Reya T, Morrison SJ, Clarke MF, Weissman IL: Stem cells, cancer, and cancer stem cells. Nature ... to the origin of ovarian cancer stem cells. Emerging evidence suggests that ovarian cancer stem cells are relatively resistant to conventional cytotoxicchemotherapeutic agents [8]. These therapies ... associated with the inhibition in the translocation of p65 subunit of NF-κB in the nucleus, which is otherwise increased by the cis-platin treatment.ConclusionIn conclusion, the evidence provided...

báo cáo hóa học:" Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role" potx

... Traditionally,this has been by the intravenous route only but there is more interest in the delivery ofintraperitoneal chemotherapy utilizing the pharmaco-therapeutic advantage of the peritonealbarrier. ... intraperitonealchemotherapy showing improved outcomes for those receiving at least part of their chemotherapyby the intraperitoneal route.Cisplatin has been the most active drug for the treatment of ovarian cancer ... front-line therapy documented at sec-ond-look surgery will recur [15].Chemotherapy The most active chemotherapy agents in ovarian cancer are the platinum analogues, cisplatin and carboplatin.The...

báo cáo hóa học:" Endometriosis-associated ovarian cancer: A tenyear cohort study of women living in the Estrie Region of Quebec, Canada" doc

... ovarian cancer, but recent datasupporting this hypothesis are lacking. The aim of this study was to verify whether the incidence of endometriosis,ovarian cancer and the both increased during the ... [11-13]. The aim of this study was to clarifyfurther the rela tionship betwe en ovarian cancer andendometriosis in the Estrie region of Quebec, Canada.Materials and methodsLocated at the CHUS ... However, the results of observational studies of the association between these two diseases are inconsistent.Some studies showed an increased risk for ovarian cancer [6-10], while other studies...

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