... with the health-related quality of lifeSharon Grimaldi*, Timo Partonen, Samuli I Saarni, Arpo Aromaa and Jouko LönnqvistAddress: National Public Health Institute, Department of Mental Health and ... or the light-dark transitions, areneeded for reset of the principal circadian clock on a dailybasis. The principal circadian clock, which is located in the suprachiasmatic nuclei of the anterior ... hypothalamusin the brain, also reacts to changes in the length of day [1]and thereby tunes the drive to its targets [2]. Changes of season challenge these time-keeping mechanisms of action as, for...