... Variation of this composi-tion such as a reduction of the number of charges orthe number of acyl chains, a change in their distribu-tion, or degree of saturation, results in a dramaticreduction of ... be interpreted to indicate that a variation of the primary structure of endotoxin molecules influ-ences their physicochemical behaviour, and that this physicochemical behaviour is correlated to ... Osaka University, Department of Chemistry, Osaka, JapanLipopolysaccharide (LPS, endotoxin), as a majoramphiphilic component of the outer leaflet of the outermembrane of Gram-negative bacteria,...