... Artemis and NHEJ proteins are recruited to the integra-tion site (5). These proteins, and likely other factors, then mediate the other steps of post integration repair, which require possibly further ... regulat-ing the ATM-Artemis-NHEJ pathway. However, NBS1 isalso a component of the MRN complex, and recruits the MRE11 nuclease of this complex to the sites of DNAbreaks [13,14]. The process of PIR ... distinctsteps: trimming the 2-bp flaps from the 5'-ends of the pro-viral DNA, filling in the single-stranded gaps that arosefrom the original staggered cleavage of host DNA, ligation of the trimmed...