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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt

Báo cáo sinh học:

Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx

... 10RESEARC H Open Access High < /b> Chromosome < /b> Number < /b> in < /b> hematological< /b> cancer < /b> cell < /b> lines < /b> is < /b> a < /b> Negative < /b> Predictor < /b> of< /b> Response < /b> to < /b> the < /b> inhibition < /b> of < /b> Aurora < /b> B and C by GSK1070916Christopher Moy*, Catherine ... 9-16.doi:10.1186/1479-5876-9-110Cite this article as: Moy et al.: High < /b> Chromosome < /b> Number < /b> in< /b> hematological < /b> cancer < /b> cell < /b> lines < /b> is < /b> a < /b> Negative < /b> Predictor < /b> of < /b> Response < /b> to< /b> the < /b> inhibition < /b> of < /b> Aurora < /b> B and C by GSK1070916. Journal of < /b> ... relationship of < /b> chromosome < /b> num-ber in < /b> primary and secondary populations of < /b> the < /b> tumorduring and after treatment to < /b> monitor potential evolvingresistance. Inhibition < /b> of < /b> Aurora < /b> B does not inhibit cell < /b> cycle...
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báo cáo hóa học:

báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot

... Cadherins, that are involved in < /b> the < /b> formation and maintenance of < /b> the < /b> histo-architecture.[19]103 Plasmonogen activator inhibitor-2 (PAI-2) Involved in < /b> the < /b> regulation and inhibition < /b> of < /b> binding between ... purposes)thesize most components of < /b> the < /b> plasminogen activationsystem. Among the < /b> numerous features shared by normalmonocytes and M4 cells were the < /b> capability to < /b> migrate to< /b> areas of < /b> inflammation ... bone marrow aspirates in < /b> compari-son to < /b> blasts from peripheral blood samples do not differbasically. This may indicate, that samples of < /b> peripheralblood with high < /b> amounts of < /b> blasts are to < /b> be...
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báo cáo hóa học:

báo cáo hóa học:" High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis" potx

... metastasis of < /b> cancer < /b> cells in < /b> the < /b> group to< /b> which ascorbic acid had been injected before injecting cancer < /b> cells into the < /b> abdominal cavity. Past research on the < /b> anticancer effects of < /b> ascorbic acid ... can inhibit angiogenesis.According to < /b> Ashino and colleagues (2003), cytopermea-bility is < /b> increased by endothelial growth factor and decreased by antioxidant, and ascorbic acid affects angio-genesis ... prevent cancer < /b> genesis and metastasis by inhibiting induction and angiogenesis. It appears that ascorbic acid inhibited the< /b> activation of < /b> cancer < /b> cells, invasion into surrounding tis-sue, or metastasis...
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Báo cáo hóa học:

Báo cáo hóa học: " Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice" pptx

... Gupta A,< /b> McCluskey B, Dubrot J, Palazon A,< /b> Azpilikueta A,< /b> Ochoa MC, Alfaro C, et al.: Therapeutic antitumor efficacy of < /b> anti-CD137 agonistic monoclonal antibody in < /b> mouse models of < /b> myeloma. Clin ... in < /b> that case, suggestingone or more antibodies in < /b> that batch of < /b> Tri-mAb wasunusually active. The < /b> effectiveness of < /b> Tri-mAb against orthotopic kidney cancer < /b> is < /b> enhanced by coadministration of < /b> ... basis of< /b> responses of < /b> ectopic inoculation of < /b> tumor cells subcuta-neously can be performed quickly and can teach us muchabout the < /b> potential of < /b> various therapeutics and give usmechanistic insight...
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Báo cáo hóa học:

Báo cáo hóa học: "High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study" pptx

... of < /b> cohort B due to < /b> severe thro mbocy-topenia. C hemotherapy was also delayed in < /b> 4 patients of< /b> cohort A < /b> and in < /b> 2 patients of < /b> cohort B because of < /b> failure of < /b> hematologic recovery prior next cycle ... 8:115http://www.translational-medicine.com/content/8/1/115Page 4 of < /b> 8PROTOCOL Open Access High < /b> activity of < /b> sequential low dosechemo-modulating Temozolomide in< /b> combination with Fotemustine in < /b> metastaticmelanoma. A < /b> feasibility ... per-formance or according to < /b> clinical requests.Objective tumor response < /b> was evaluated according to < /b> Response < /b> Evaluation Criteria In < /b> Solid Tumors (RECIST)criteria. A < /b> complete response < /b> (CR) was...
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báo cáo hóa học:

báo cáo hóa học:" Hypothetical membrane mechanisms in essential tremor" pdf

... motor control?Increases in < /b> membrane excitability could affect motorcontrol in < /b> many ways. One mechanism is < /b> by destabilizing the < /b> circuits comprised of < /b> reciprocally innervated neurons.Such circuits ... following section we introduce a < /b> concept explaining the < /b> basis of < /b> oscillations in < /b> reciprocally innervated circuitswhen external inhibition < /b> is < /b> intact.Concept 2 – Increased excitability can make ... hypothesis with a < /b> conductance based computationalmodel that simulates tremor.Concept 1 – Sherrington's 'burden': reciprocal inhibition < /b> and rebound depolarizationExcitation of < /b> an agonist...
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báo cáo hóa học:

báo cáo hóa học:" GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment" pptx

... proteins. Six monomers of< /b> connexin proteins associate to < /b> form a < /b> transmembranehexameric gap junction hemi-channel called a < /b> connexon.Connexons embedded in < /b> the < /b> surfaces of < /b> adjacent cellsassociate ... province), Tongzhou School for the < /b> Deaf and Dumb (Jiangsu province), Jilin Special Education School (Jilin province), Yin-chuan School for the < /b> Blind, Deaf and Dumb (Ningxia Province), Xining ... introns by PCR/sequencing. The < /b> PCR primers used are forwardprimer:5'CTCATGGGGGCTCAAAGGAACTAGGAGATCGG3' and reverse primer 5'GGGGCTGGACCAACACACGTC-CTT GGG3'. The < /b> PCR products...
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báo cáo hóa học:

báo cáo hóa học:" Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival" doc

... metastasis of < /b> a < /b> well differentiated carcinoma of < /b> the< /b> stomach taken prior to < /b> cytotoxic therapy. According to < /b> the< /b> manufacturer's datasheet, cells express the < /b> surface glyco-proteins carcinoembryonic ... that CK19 and CEA are markers of < /b> CTC presence but not necessarily of < /b> CTC ability to < /b> metastasize: in < /b> fact, it is < /b> well acceptedthat only a < /b> subset of < /b> CTC has the < /b> biological potential of< /b> giving rise ... stratification and ultimately personalize the < /b> therapeutic management of < /b> thesepatients.BackgroundGastric cancer < /b> represents the < /b> fourth most common cancer< /b> and second leading cause of < /b> cancer-< /b> related...
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Báo cáo hóa học:

Báo cáo hóa học: " Non-monotonic changes in clonogenic cell survival induced by disulphonated aluminum phthalocyanine photodynamic treatment in a human glioma cell line" pot

... tubulin may be caused by an increase in< /b> PDT induced intracellular calcium (Ca2+) [52]. Role of< /b> calcium in < /b> photofrin and phthalocyanine mediated pho-tohemolysis and apoptosis in < /b> rabbit red blood ... Gupta S, Dwarakanath BS, Muralidhar K, Jain V: Cellular uptake, localization and photodynamic effects of < /b> haematoporphyrin derivative in < /b> human glioma and squamous carcinoma cell < /b> lines.< /b> J Photochem ... Stockert JC, Villanueva A,< /b> Polo S, Dominguez V, Canete M: Photodamage induced by Zinc(II)-phthalocyanine to < /b> microtubules, actin, alpha-actinin and keratin of < /b> HeLa cells. Photochem Photobiol 2001,...
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Báo cáo hóa học:

Báo cáo hóa học: " Effective knowledge management in translational medicine" doc

... D,Barrette T, Pandey A,< /b> Chinnaiyan AM: Large-scale meta-analysis of < /b> cancer< /b> microarray data identifies common transcriptional profiles of < /b> neoplastictransformation and progression. Proc Natl Acad ... subjectswith primary melanoma, or basal cell < /b> carcinoma orsquamous cell < /b> carcinoma and the < /b> second cohort con-sist of < /b> samples from tissues from subject w ith meta-static melanoma. The < /b> example shows the < /b> resultingheatmap ... 8:68http://www.translational-medicine.com/content/8/1/68Page 3 of < /b> 9These databases allow bioinformaticians to < /b> downloadthenormalizeddataandcarryoutfurtheranalysis .The< /b> typical setting for such analyses that the < /b> scientist posessome...
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