o cáo hóa học:" A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols" pot
Báo cáo sinh học: " A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols" pot
... labs to use theirown protocol for thawing, staining, gating, and data ana-lysis. Each laboratory performed two parallel assays, onewith and one without the inclusion of dump channel markers. The ... provided byindividual laboratories. In addition, to minimize the impact of individual laboratory gating, analysis, andinterpreta tion strategies, a censored analysis was alsoperformed. For the ... et al.: A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols. Journal of Translational Medicine 2011 9:108.Submit your next manuscript...
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báo cáo hóa học:" A practical approach for the validation of sterility, endotoxin and potency testing of bone marrow mononucleated cells used in cardiac regeneration in compliance with good manufacturing practice" docx
... cleavage of a synthetic substrate by an enzyme produced in the reaction of the lysate in the presence of endotoxin. The system con-sists of LAL reagents and endotoxin controls in the form of a single-use ... potency.Endotoxins are lipo-polysaccharides from gram-negativebacteria and are the most common cause of toxic reactionsresulting from contamination with pyrogens: the absence of bacterial endotoxins in a product ... measure the ability of certain cell types to move through a porous membranetoward a chemoattractant or growth factor. In contrast to cell migration through an open pore, cell invasionthrough...
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báo cáo hóa học: "A binary method for simple and accurate two-dimensional cursor control from EEG with minimal subject training" potx
... (locked -in syndrome), it mustwork in the absence of hand movements. The state of the art in BCI research is to use motor imagery in place of realmovement to attempt to replicate the effects of paralysis.This ... cursor move was correct. For motor imagery, no EMG signal was available for com-parison, so we assessed the accuracy of yes/no classifica-tion from one of the threshold-setting task recordings. ... featuressomewhat unnatural control methods (hand, foot, andtongue motor imagery), as well as variable accuracy andhigh computational demand. Thus, self-pacing is not the only obstacle to naturalistic...
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Báo cáo hóa học: "Adaptive robot training for the treatment of incoordination in Multiple Sclerosis" doc
... we investigate a robotic approach to neuro-motor rehabilitation of MS subjects that com-bines, in the same protocol, the evaluation of motor per-formance and the fine tuning of the training ... of performance at the end of the adaptation phase as com-pared to the final portion of the wash-out phase. Onesubject (S8) did not complete the second half of the trial, for reasons unrelated to the ... that adaptation to error-enhancing perturbations(error-enhancing t raining) can induce short-termimprovements of motor performance. In contrast, adap-tation to perturbations that opposed the...
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Báo cáo Y học: A critical motif for oligomerization and chaperone activity of bacterial a-heat shock proteins pot
... required for the formation of active a- Hspoligomers. In an attempt to narrow down the critical determinants to the amino-acid level, we tested the effect of two singleamino-acid exchanges (P 8A and ... and analyzed them by gel filtration, citrate synthaseassay and coaffinity purification. Truncation of more than the initial few amino acids of the N-terminal region led to the formation of distinct ... japonicum a- Hspproteins, the isolated a- crystallin domain of HspH was notsufficient for dimer formation. Only the presence of a C-terminal portion of the N-terminal region enabled the a- crystallin domain...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... individuals and/orcure the overt disease. The induction and maintenance of long lasting tolerance to islet autoantigens remains a majorgoal of T1 D research. CD4+Treg cells represent majorplayers ... as IL15RA, and the authorscould not pin-point the causal variant with the locus[28]. The genetic interval was significantly narroweddown thanks to the power of GWAS performed onlarge cohorts ... inflamma tion. Whether or not those events thatare transla ted into the blood encompass autoantigen-specific Treg cell defects remains to be determined.Modulation of the IL-2/IL-2R pathway for...
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Báo cáo hóa học: " A novel method for neck coordination exercise – a pilot study on persons with chronic non-specific neck pain" docx
... device and method for neck coordination training. The aim of the study was to investigate the clinical applicability of the method and to obtainindications of preliminary effects on sensorimotor ... a sam-pling rate of 60 Hz. Two receivers, one positioned on the forehead and the other above the dorsal spinal process of Th2, were used for recording the axial head rotation rela-tive to the ... the subjects could finecontrol the positioning of the ball. The location of the ballat starting and target positions was monitored by LED-photocell detectors. The signals from these detectors...
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báo cáo hóa học: " A rehabilitation tool for functional balance using altered gravity and virtual reality" potx
... a device to address this issue and conducted a training study for proof of concept of efficacy.Methods: We present a tool that can enhance the concept of BWS training by allowing natural APAs to occur ... frontal plane. A cable attached to the lower part of the frame runs between the legs of the subject to a pulleymounted on a linear bearing allowing mediolateralmotion of the pulley before connecting ... to enhanced use of somatosensory, visual and/orlinear and angular acceleration information from the ves-tibular system. The shorter critical time parameter of the Stabilogram-Diffusion analysis...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... return following dorsal root rhizotomy. We speculate that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere ... to the bone and capsular tissue. Limitations of the current study include a lack of comparison group and lack of blinding. A rando-mized, controlled clinical trial would be ideal to fur-ther ... varied based on the size of the portal and ranged from 2.7 to 7mm in diameter. Electrocau-tery and holmium lasers are also used to complete the denuding of the joint surface to insure that...
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Báo cáo khoa học: "A Formula Finder for the Automatic Synthesis of Translation Algorithms" docx
... Professor Anthony Oettinger and of his other colleagues at the Harvard Computation Laboratory. semiautomatic synthesis of translation algorithms from empirical data, a means of formula finding ... back onto magnetic tape for input to a computer. The operation of the proposed system is based on the automatic comparison of magnetic tapes containing the original automatic dictionary outputs ... a factorization of Ts into a product of machinable algorithms applicable to situations com- monly occurring within sentences. For purposes of automatic formula finding, a specific type of...
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