báo cáo hóa học:" Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx

báo cáo hóa học:" Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells" pot

... patient sample. While the overall number of cells that stained positive for Aurora-A were higher in the carcinomas due to increased epithelial content, the inten-sity of the staining was equivalent ... Aurora-A staining of TMA core of benign ovarian tissue (20×). (G) Aurora-A staining of TMA core of ovar-ian carcinoma with adjuvant chemotherapy (20×).Journal of Translational Medicine 2008, ... of PTX0 cells. PTX10 cells harbor a point mutation in the M40 β-tubulin isotype resulting in a phenylalanine tovaline mutation [39] which may alter the binding of pacl-itaxel to microtubules. It...

Báo cáo hóa học: " LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer" pptx

... cells,while the intensity of staining was not considered. Todetermine the combined influence of LEF-1 and TCF4on tumorigenesis, a LEF-1/TCF4 score was generated.Therefore, negative staining of LEF-1 ... rvival. These surprising findingssuggest that TCF4 might be the main binding partnerfor b-catenin during development and progression of colorectal cancer whereas an enhancement of Wnt/b-catenin ... b-catenin posi-tivity, but lacked LEF-1 and TCF4 expression. Thesefindings suggest that activation of the Wnt signallingpathway as indicated by the presence of nuclear b-cate-nin staining,...

báo cáo hóa học: " How does asthma influence the daily life of children? Results of focus group interviews" pot

... drawing about something they felt wasrelated to their asthma. The moderator used the draw-ings for the facilitation of the discussion during the firstsession [18,19]. In the second session, the ... dis-cussed, the moderator started with the nominal grouptechnique (NGT) in the third session [20]. Instead of the traditional voting procedure used in the NGT, the moderator asked the children to imagine ... to improve the HRQL of the p ediatricasthma patient, since the components of HRQL that arebothering the pediatric asthma patient can be integrated in medical care decisions for the individual...

báo cáo hóa học: " Body mass index and health related quality of life in elementary school children: a pilot study" pdf

... where the inter- action of the physical, social, mental and emotional deter-minants of health are of interest. Health indices are useful in health policy and economic evaluation, because a sin-gle ... description of the survey is reported elsewhere[7]. In the spring of 2004, our investigation surveyed par-ents of children enrolled in an elementary school, kinder-garten to fourth grade, in southern ... lose weight in a healthymanner, thus reducing their BMI, could also improve theirphysical and psychosocial health.Competing interests The authors declare that they have no competing interests.Authors'...

Báo cáo hóa học: " Innovative gait robot for the repetitive practice of floor walking and stair climbing up and down in stroke patients" pdf

... climbing up and down in line with the task-specific repetitive approach. However the inherent physi-cal effort of the therapists limit the intended intensity, afurther burden is the risk of ... fixed to the back end of the linear guide. The for-ward and backward excursion of the principal sledgeensured the control of the step length. The mechanicdesign for the control of the step ... realizedimplementing the scissor principle. The second sledge on the linear guide moved relatively to the principal sledge.A rod ensured the connection of the relative sledge to the pivoting arm. Nearing the...

báo cáo hóa học: " Simvastatin inhibits interferon-γ-induced MHC class II up-regulation in cultured astrocytes" potx

... assess-ing simvastatin in patients with relapsing remitting MSrevealed a significant reduction in gadolinium-enhancinglesions on magnetic resonance imaging of the brain,which is indicative of ... test the effects of statins in MS are ongoing.Statins reduce the migration of leukocytes into the centralnervous system (CNS), induce a Th2 phenotype in T-cells,and decrease the expression of ... University of Groningen, Groningen, The Netherlands and 2Cell Biology (Immunology Section), University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsEmail: Esther Zeinstra...

Báo cáo hóa học: " Bioinformatic analysis suggests that the Orbivirus VP6 cistron encodes an overlapping gene" potx

... codons in each of the 48 sequences in each of the three forward reading frames. Note the conserved absence of stop codons in the +0 frame (i.e. the VP6 CDS) and in the +1 frame in the ORFX region. ... (ends) of the window. See [16] for further details of the MLOGD software. In (5)–(6) the null model, in each window, is that the sequence is non-coding, while the alternative model is that the ... scoring windows in the ORFX region. Moreover, the MLOGD results showed that,within the ORFX region, ORFX is more conserved at the amino acid level than VP6 (Figure 2). Finally, inspection of the...

Báo cáo hóa học: " Viable chimaeric viruses confirm the biological importance of sequence specific maize streak virus movement protein and coat protein interactions" pdf

... were exchanged, no intra-ORF or intra-protein inter-actions were disrupted in the chimaeras.Determinants of chlorotic severity In view of the number of known – as well as the manylikely but ... an isolate of the MSV-A strain,which is the predominant MSV strain infecting maize in Africa [25,26]. MSV-Set, on the other hand, is one of onlytwo characterized representatives of the Setaria-adaptedMSV-C ... arisefrom intricate webs of highly specific interactions betweennumerous distinct genetic sequence elements. One mightimagine that the structures of these genetic interactionnetworks define the...

Báo cáo hóa học: " Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production" docx

... designed to investigate the biological significance of the Cav-1-Gag interaction.We reasoned that overexpression of fusion proteins con-taining the CBD of MA could block the interaction of Gagwith ... co-localizepredominantly in punctate patterns at the PM and tolower extent in perinuclear regions of the cell. Sequencecomparisons uncovered a Cav-1 binding domain in the matrix domain MA of the Gag ... Co-immuno-precipitations revealed that both proteins inter-act presumably via a caveolin-binding domain (CBD)within the aminoterminal region of MA. The CBD ishighly conserved in Gag of most γ-retroviruses and com-petition...

báo cáo hóa học:" A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" doc

... G2/M c heckpoint and in decreasing the number of cells in G2/M. At the same time, reduced levels of cyclinswoul d negatively control the cell cycle checkpoints. The combination of cell cycle ... stages of CRC carcinogenesis [37]. There-fore, early during CRC carcinogenesis, an effect ive cyto-toxic effect induced by 5-FU in the KIAA0247-expressing cells could be crucial in controlling the ... Medicine 2011, 9:82http://www.translational-medicine.com/content/9/1/82Page 6 of 8nucleus and repress the progression of the cell cycle at the G2/M phase supported the clinical findings. The downregulation...

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