báo cáo hóa học:" Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" pot

... combination with IL-13- PE but with other immunotoxins for therapy of pancreatic cancer and other cancers. Introduction Interleukin-13 Receptor a2(IL-13Ra 2) is a high affinity receptor for the ... HDAC inhibitors in syngenic animal tumor models. Taken together, our results provide support for testing this novel combination in the clinic for the ther- apy of human canc...

Ngày tải lên: 20/06/2014, 03:20

... Fujisawa et al.: Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer. Journal of Translational Medicine 2011 9:37. Submit ... RESEARC H Open Access Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of...

Ngày tải lên: 18/06/2014, 19:20

... if the observed differences in replication in mice reflect real differences in the biology of these viruses, or are related to differences in the animal models including route of infec- tion. In ... deamina- tion of cytosine and can result in A:T transition mutations in one of the nascent strands [1]. Minimizing the incorpo- ration of these bases and excisi...

Ngày tải lên: 20/06/2014, 01:20

... and the flanking chromatin [9]. These findings indicate that the action of DSB-interactive proteins within the nuclear micro- environment must be coupled with the mobile state of those proteins. Keywords coacervate; ... (ii) the concentration of factors diluted in solution; (iii) the acceleration of reactions; and (iv) the involvement of DNA aggrega- tion-promoting fac...

Ngày tải lên: 19/02/2014, 06:20

... that the nicking of the 123- residue chain polypeptide chain causes an untighting of the structural domains of LA (see Fig. 1), determin- ing exposure of hydrophobic patches. Furthermore, the ... at the level of the b-subdomain of the 123- residue chain of the protein (Fig. 1). We have also characterized the early stages of protein aggregation in order to g...

Ngày tải lên: 30/03/2014, 16:20

... observations about the role of exosomes in antigen presentation, the exacerbated production of these vesicles by tumor cells was initially welcomed as a process potentially involved in the induction and maintenance ... thanks to the recovery of specific immunity and the interruption of paracrine/autocrine loops in tumor microenvironment. Prior to any clinical intervent...

Ngày tải lên: 18/06/2014, 15:20

... proteins in the tumor tissues. As shown in Table 1, survivin expression was detected in all the cases by immunostaining. Though there were some differences in the staining intensity among the ... potency of CTL induction in various cancer patients including breast cancer, colorectal cancer, and gastric cancer patients [23]. On the basis of these findings in vitro, cl...

Ngày tải lên: 18/06/2014, 15:20

... of CAV1 enhances the transport of RES into HepG2 through its cholesterol shuttle domain rather than the scaffolding domain. This leads, in turn, in inhibition of proliferation and induction of ... caveolin- 1 that binds to and inhibits the activity of several signaling proteins in vitro and in situ, including the EGF and Neu receptors, Src-family kinases (Src/Fyn),...

Ngày tải lên: 18/06/2014, 15:20

... road to the combined application of heat shock pathway and oncolytic adenovirus for tumor treatment in the future. Competing interests The authors declare that they have no competing interests. Authors' ... < 0.05). The HSE activity was corresponding to the cytotoxicity of Adel55. The higher is the HSE activity, the more cytotoxicity of Adel55 is to the cells...

Ngày tải lên: 18/06/2014, 16:20

... drafted the manuscript. MH and TC assisted in the design of the study and in the drafting of the manuscript. SL assisted in the conducting of inter- views, analysis of the data and the drafting of the ... point whereby no new information was gathered regarding the treatment impact of inhaled and pump delivered insulin. This data was then combined with th...

Ngày tải lên: 18/06/2014, 19:20