... immunotherapy combined with chemotherapy in a first-line setting with patients with a good immune status, as here, but in randomized phase II and III clinical trials with standard chemother- apy ... 1.25 and 6.25 mg). IMP321 induced both a sustained increase in the number and activation of APC (monocytes and dendritic cells) and an increase in the percentage of NK a...
Ngày tải lên: 18/06/2014, 16:20
... equivalent with voting over income distributions as in Grandmont [8]. Conditions (2) and (3) insure that every tax is increasing with the revenues in such a way that it does not change the post-tax income ... (Marhuenda and Ortu˜no-Ortin [6]), considering solution concepts less demanding than the core (De Donder and Hindriks [10]). In a majority game in coalitional form of v...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Hypothetical membrane mechanisms in essential tremor" pdf
... patients is determined by both I h and I T . Tremor frequency increases with increasing I h and decreases with increasing I T . In summary, simulations support our hypothesis that an increase in premotor ... were increased. The increase in these currents resulted in alter- nating bursts of action potentials in the neurons innervat- ing the sets of agonist and antagonist mu...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" GJB2 mutation spectrum in 2063 Chinese patients with nonsyndromic hearing impairment" pptx
... province), Yin- chuan School for the Blind, Deaf and Dumb (Ningxia Province), Xining Spe- cial Education School (Qinghai province), Changan School for the Deaf and Dumb (Shaanxi province), Affiliated ... (Sichuan province), Urumchi School for the Deaf and Dumb (Xinjiang province), Korla School for the Deaf and Dumb (Xinjiang province), Kunming Huaxia Secondary School (Yunnan provi...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... cardiac intensive care with the cath- eter remaining in place for drug initiation and monitoring as per standard care. Exclusion criteria included exposure to intravenous inotropic support within ... ino- trope administration and dosing. Procedures All treatments including milrinone dosing was at the dis- cretion of the patient's attending physician, with initial dosing between...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival" doc
... these findings in larger prospective and multicentric series might lead to the implementation of this biomarker in the routine clinical setting in order to optimize risk stratification and ultimately ... TNM stage and Survivin mRNA levels measured in the peripheral blood independently predict patients' OS. The hazard ratio (HR) associated with Survivin levels indicates th...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: " Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice" pptx
... (Figure 5). Interestingly, in one experiment, mice received just one injection of Tri-mAb (with or without IL-2) or three injections of Tri-mAb (with or without IL-2), and when long-term surviving mice ... against estab- lished orthotopic and metastatic renal cell carcinoma without nephrectomy and ascertain if treatment could be optimized using cytokine support. Materials and meth...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Non-monotonic changes in clonogenic cell survival induced by disulphonated aluminum phthalocyanine photodynamic treatment in a human glioma cell line" pot
... AlPcS 2 following incubation of cells with AlPcS 2 in HBSS for different time intervals showed rapid and linear increase in the accumulation of AlPcS 2 in the first 2 h, prolonged incubation (up ... pre-incubation. Relationship between surviving fraction and energy was quantified by modeling the data with a univariate lin- ear regression analysis with energy being an independ...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats" pptx
... following ADMSC treatment. Accordingly, the results of the pres- Figure 5 Oxidative index in brain infarct area. Western blotting showing notably increased oxidative index, protein carbonyls, in ... markedly elevated in group 2 compared with that in groups 1 and 3, and notably lower in group 1 than in group 3. These find- ings indicate that ADMSC transplantation exerted bot...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Effective knowledge management in translational medicine" doc
... a set of translational and biomarker groups and focusing also on the management and mining of the data emanating from integrative settings crossing the drug discovery and development stages. ... carcinoma samples shown in Figures 3a-c. Interestingly, comparing basal cell carcinoma samp les with metastatic carcinoma samples using the Comparati- veMarkerSelection algorithm [24] buil...
Ngày tải lên: 18/06/2014, 16:20