Báo cáo hóa học: " Members of the Hyposoter didymator Ichnovirus repeat element gene family are differentially expressed in Spodoptera frugiperda" docx

... segment containing the corresponding gene (except for Hd ichnovirus) then the rep gene number. Arrow-heads indicate beginning and ending of the conserved repeated element motif as defined by Theilmann ... rep11 lacks the C-terminal part of the repeated element motif, comparedto the other rep proteins.Whole rep protein sequences of several Ichnoviruses con-taining a single repeat and accessible ... segments, members of the rep family possess a conserved 540-bp repeated element motif, found singly or in multiple repeats [9-12]. The rep gene family is the largest conserved ichnovirus gene fam-ily...

Báo cáo hóa học: " Usefulness of Herpes Consensus PCR methodology to routine diagnostic testing for herpesviruses infections in clinical specimens" docx

... only in one HSV-1 positivepatient the examination of the fundus of the eye revealedposterior uveitis and inflammatory changes of retinal ves-sels (vasculitis). On the other hand VZV intraocular ... assay in Greece. The assay's ability to detect herpesviruses in a wide range of specimen types in a single amplification enhances its util-ity in the clinical setting, by avoiding the need ... facilitate the routine diagnosis of herpesvirusesinfections, within a single assay, single clinical sample,thereby allowing earlier application of specific antiviraltreatment and better clinical...

báo cáo hóa học:" Summary of the primer on tumor immunology and the biological therapy of cancer" ppt

... difficult to generate large numbers of high aviditytumor-reactive CD8+ T cells in individual patients in timeand maintain their survival in vivo. The solution is gene therapy, by engineering T cells ... patients withmelanoma in combination with high dose IL-2 has beenshown to achieve clinical responses in the range of 50%.However, minimal activity of IL-2 in the treatment of other cancers has been ... targeting tumor angiogenesis byblocking the VEGF/VEGFR pathway. Growth factors of the VEGF and PDGF families function primarily in a paracrinemanner to promote angiogenesis (the sprouting of newblood...

báo cáo hóa học:" Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model" docx

... and ointment vehicle.Clinical rating was performed twice a week during the treatment phase assessing the Total Clinical Score (TCS). The Total Clinical Score is defined as the sum of erythema(0-3), ... positively stained epidermal area,i.e. the area of positive CK10 or CK16 in relation to the total epidermal area. These measurements were per-formed with the Visiopharm Integrator System software(VIS, ... demonstrates the feasibility of obtaining robustbiomarker data in the psoriasis plaque test that correlatewell with those obtained in other clinical studies. Further-more, the biomarker data from the...

Báo cáo hóa học: " Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032" potx

... in culture; HMK,participated in writing of the manuscript; DN, excised tumors and provided the material for research; RH, in charge of analyzing tumor specimens andparticipated in writing the ... between the V600E and V600K mutations. Ourpreclinical data demonstrating s imilar kinase activity of the V600K and V600E mutations, together with clearevidence of clinical activity of PLX4032 in ... treatment to the specific genetic composition of the tumor [5].One of our patients with locally advanced unresectablemelanoma inv olving the skin of the l eft chest wall, pro-gressing after treatment...

Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt

... significant increase of NGF, BDNF and NT-3 transcripts and NGF proteins in both the NSCcultures and the CSF of the rats. The immunochemical staining for MHC in brain sections and the enzyme-linkedimmunosorbent ... staining.Immunohistochemistry stainingImmunohistochemical staining of nestin and BrdU wereperformed to assess the property of NSC in cultures andtrack the migration and homing of allogeneic BrdU-labeled NSC in the host ... futurestudies.Conclusions The findings presented here provide further insights into the mechanisms of NSC in the regeneration of the CNS.Should the MHC modulation mediated by NSC-derivedneurotrophins be elucidated,...

Báo cáo hóa học: " Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer" ppt

... importantrole in the stabilization of mRNA by reversibly bindingto conserved sequence elements, most often AU-richelements (AREs), in the untranslated regions (UTRs) of the mRNA resulting in either ... implicated in cisplatin resistance, i.e.decreased drug uptake, insufficient DNA-binding of the drug, increased DNA-repair of cisplatin adducts and fail-ure of induction of apoptosis, reviewed in [2,5,7]. The ... predict cisplatin response in EOC. Further studies are required to evaluate the role of RBM3 in predictingrespons e to other platinum based agents, particularly in the setting of a prospective...

Báo cáo hóa học: " Prevalence of the GJB2 IVS1+1G A mutation in Chinese hearing loss patients with monoallelic pathogenic mutation in the coding region of GJB2" pot

... mutation in the GJB2 gene with either rece ssive or unclear pathogenicity, despitedirect sequencing of the entire coding region of the gene [12-14]. The ratio of a 309-kb deletion involving the GJB6 ... orother noncoding regions of GJB2.To evaluate the impact of the IVS1+1G>A splice-sitemutation and the b asal promoter region in the noncod-ingpartoftheGJB2geneamongChinesepatients,weinitially ... pattern of inheritanceis resp onsible for these cases. Therefore, the secondmutation may be a connexin gene other than GJB6or may involve another gene, the product of whichinteracts with connexin...

Báo cáo hóa học: "Evaluation of the anti-angiogenic properties of the new selective aVb3 integrin antagonist RGDechiHCit" potx

... RGDechiHCit in the selective inhibition of endothelial aVb3integrin in vitro and in vivo. Such inhibition opens new fields of investigation on the mechanisms of angiogenesis,offering clinical ... proteins containing the RGD triad,many studies have demonstrated that the aminoa cidsflanking the RGD sequence of high-affinity ligandsappear to be critical in modulating their specificity of interaction ... experimental setups.Indeed, of the wide spectrum of integrins that are expressed on the surface of ECs, aVb3receptor has beenidentified as having an especially interesting expressionpattern...

báo cáo hóa học: "Impact of gastroesophageal reflux disease on patients'''' daily lives: a European observational study in the primary care setting" doc

... including the RDQ, GIS and the Gastrointestinal Symptoms Rating Scale, may be onesuch instrument, providing more accurate and sensitivequantification of the symptoms and the impact of these in patients ... within the specified identification period wereincluded in the study population and irrespective of the number of times they visited that practitioner. Also, the high rate of acceptance among the ... by use of one questionnaire alone.Thus, RDQ allowed for an evaluation of the frequency andintensity of GERD symptoms, the GIS providing compli-mentary information in terms of the use of additionalmedication...

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