Báo cáo hóa học: " Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that ?" doc
Báo cáo hóa học: " Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that ?" doc
... affinity to that exhibited by the Nef :SH3 domain interaction. We conclude that NS5A binds to SH3 domains with high affinity, and such interactions couldoccur in the context of an HCV infected cell.Results ... interactions with the SH3 domain of the Src-family tyrosine kinase, Fyn. Surface plasmon resonance analysis revealed that NS5A binds to the Fyn SH3 domain with what can be considered a high affinity ... We conclude that the NS5A: Fyn SH3 domain interaction occurs via a canonical SH3 domain binding site and the high affinity of the interaction suggests that NS5A would be able tocompete with cognate...
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Báo cáo hóa học: " Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression" potx
... 5'-GTACGGGGATCCTTATCAG-CACTCTTCCATCTCATCGAACTCCTG-3', F gene; 5'-AAAAAAAAGGATCCACCATGGCACGAATCCTAAACCT-CAAAGA-3', 5'-TTTCCCTGGGATCCTTATCACGCCGTCT-TCCAGAACCCG-3' (initiation codon ... 5'-GGGACGCGTTTAAACCAATGGCA-GAAGCTCC-3' and 5'-TGCGGTACCGGCTAAATCG-CAACTGCTTCCCCAG-3' (for IFN-λ1 promoter), 5'-GCAACGCGTCATATTCCTGAGTCCTTCCTTGC-3' and 5'-CCCGGTACCGTCTGTGTCACAGAGAGAAAGGGAG-3'(for ... by PCR andinserted into the BamHI site of pcDNA3.1(+)-FLAG-tagged expression vector [43]. Primers for NS3/4A; 5'-AAGGGGGGATCCACCATGGCGCCCATCACGGCG-TACGCCCAGCAG-3', 5'-GTACGGGGATCCTTATCAG-CACTCTTCCATCTCATCGAACTCCTG-3',...
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báo cáo hóa học:" Hepatitis B virus X protein interacts with β5 subunit of heterotrimeric guanine nucleotide binding protein" docx
... pACT-MyoD. The negative control reaction consisted of 0.4 ng of each of the following vectors, pG5luc, empty pACT vec-tor and the GNβ5-pBIND vector. The actual experimentalreaction to confirm the ... designed with NcoI and PstI enzyme restriction sites as follows:5'-TGCCATGGCAATGGCTGCTAGGCTGTACTGCC-3'5'-AACTGCAGTTAGGCAGAGGTGAAAAAGTT-3' The PCR product and the binding domain ... 0.186. Theyexceeded the calculated cut-off of 0.179, thus indicating the presence of HBsAg. The results of this assay run werevalid as the criteria for the quality control had been met. The mean...
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Báo cáo hóa học: " Hepatitis B virus and hepatitis C virus in pregnant Sudanese women" doc
... appliedto gather relevant socio-demographic characteristics of these women (age, education, gestational age, parity, resi-dence, occupation). Then the possible risk factors (history of surgery ... none of the expectedrisk factors (age, parity and the other socio-demographiccharacteristics) for sero-positivity for HBVsAg had beenidentified in the current study. The explanations for suchneed ... Anti-HCV.Authors' contributionsRME and AAD carried out the clinical study and partici-pated in the statistical analysis and procedures, MAE par-ticipated in the analysis, IA coordinated and participatedin...
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Báo cáo y học: "Hepatitis C Virus (HCV) Infection and Hepatic Steatosis"
... occur when the HCV core protein is strongly expressed. [26] The core protein has been located at the surface of lipid droplets within the cytoplasm in cell cultures that are transfected with ... that the hepatitis C virus, in and of itself, can directly induce cytoplasmic lipid accumulation. Further studies examining the genotype 3 virus are warranted to further recognize the process ... of fibrosis ultimately towards cirrhosis. The other form of steatosis occurs as a direct result of the HCV genotype 3 virus through complex interactions between the HCV core protein and the...
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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
... marker profiles can be observed according to the presence or absence of either marker. The presence of HCV RNA in the absence of anti-HCV antibodies is strongly indicative of acute HCV infection, ... professional societies, currently acting as the Scientific Secretary of the European Association for the Study of the Liver (EASL), and he is a member of the Scientific College of the French National ... and 6 (C) . Int. J. Med. Sci. 2006, 3 37Chronic hepatitis C In patients with clinical or biological signs of chronic liver disease, chronic hepatitis C is certain when both anti-HCV antibodies...
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Báo cáo hóa học: " Hepatitis B virus (HBV) genotypes in Egyptian pediatric cancer patients with acute and chronic active HBV infection" ppt
... for second-round PCR weredesigned on the basis of the differences in the sizes of the genotype-specific bands. The type-specific primers weredesigned on the basis of the conserved nature of thosesequences ... infections accountedfor 45.5% of the total mixed infections. We conclude that HBV mixed genotype infections could probably be of clin-ical significance in HBV-induced liver diseases. In light of the ... 1997, 25:216-222.21. Kao JH, Chen PJ, Lai MY, Chen DS: Occult hepatitis B virus infec-tion and clinical outcomes of patients with chronic hepatitis. C J Clin Microbiol 2002, 40(11):4068-71.22....
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báo cáo hóa học:" Hepatitis B Virus: Inactive carriers" docx
... (G1896A),which creates a stop codon in the precore region of the HBV genome and completely abolishes the production of HBeAg [35]. Other variants include changes in the startcodon of the precore region ... superinfection with other hepatotropic viruses. Asmany as 20 to 30% of these acute exacerbations may becaused by superinfection with HDV, HCV, or hepatitis A virus and can be associated with an increased ... factors (gender, age, and immune status), andexogenous factors such as concurrent infection with otherhepatotropic viruses or alcohol. The clinical spectrum of HBV infection ranges from subclinical...
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Báo cáo sinh học: " Hepatitis B virus X protein interacts with β5 subunit of heterotrimeric guanine nucleotide binding protei" pptx
... restriction sites as follows:5'-TGCCATGGCAATGGCTGCTAGGCTGTACTGCC-3'5'-AACTGCAGTTAGGCAGAGGTGAAAAAGTT-3' The PCR product and the binding domain vector, pGBKT7 of 7.3 kb (MATCHMAKER ... 0.186. Theyexceeded the calculated cut-off of 0.179, thus indicating the presence of HBsAg. The results of this assay run werevalid as the criteria for the quality control had been met. The mean ... the MATCHMAKER Library Construction and Screening Kit(Clontech Laboratories, Inc) First strand cDNA synthesiswas carried out using 1 µl of a random CDS III/6 Primer:5'-ATTCTAGAGGCCGAGGCGGCCGACATG-NNNNNN-3',...
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Báo cáo y học: "Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection"
... the prevalence and clinical significance of occult HBV infection in patients with chronic hepatitis C. The result showed that 21 of the 66 patients with HCV infection and occult HBV infection ... combined effect of HBV and HCV coinfection on HCC? Accumulated epidemiological data suggested that coinfection with HBV and HCV could increase the risk for development of HCC. A case-control study ... investigate the risk of fulminant hepatitis C in relation to concurrent infection of HBV. Of 109 patients with acute hepatitis C, 11 patients (10.1%) had the complication of FHF. The occurrence of...
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