Báo cáo hóa học: " Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two coiled coil motifs in the nucleoprotein" pdf

... address the question of whether the interaction domain for VP35 is present in the coiled coil region itself or whether the coiled coil region is necessary to support the integrity of the VP35 binding ... citation purposes) Virology Journal Open Access Research Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two c...

Ngày tải lên: 20/06/2014, 01:20

... coiled coil domains is essential for the function of NP in RNA synthesis. Discussion Coiled coil motifs are versatile domains that mediate the interaction of proteins [16]. The central feature of coiled coil ... ∆C2). These data indicate that the coiled coil region of NP influences the interaction with VP35. To address the question of whether t...

Ngày tải lên: 18/06/2014, 18:20

... observation. The sizes and loading ratio of NPs on SWNTs can be controlled by altering temperature, the ligand, and the initial concentrations of the metal ions. It is worth to note that the loading ... envir- onment, and even biomedicine. Additional material Additional file 1: Supporting information. Experimental details, the proof of π-π interaction between ligan...

Ngày tải lên: 21/06/2014, 06:20

... have only focused on bloodstream infections. However, lim- ited information is available regarding the spectrum and microbiology of these infections in sites other than the bloodstream, such as the ... therapy. Abbreviations RTI: Respiratory Tract Infections; SI: Skin Infections; UTI: Urinary Tract Infections; GITI: Gastro-intestinal Tract Infections; BSI: Bloodstream Infectio...

Ngày tải lên: 18/06/2014, 15:20

... based on the International Conference on Harmonization of Pharma- ceuticals for Human Use, which standardizes the poten- tial interpretation s and applications of the corresponding recommendations ... the donor, the research or hospital center, and the principal investigator of the project of an informed consent that explains in detail the potential risks an...

Ngày tải lên: 18/06/2014, 16:20

... lower in cases of somatic pain, physical symptoms and ineffec- tive body functioning [7]. We were therefore interested in testing this hypothesis and examining whether there is a relationship ... sample, so these findings cannot be generalized to the whole elderly population of France. Conclusion The findings suggest that the French version of the GHQ- 12 is a reliab...

Ngày tải lên: 18/06/2014, 19:20

... negotiation of the environment in which we walk. MTC while walking occurs during the mid-swing phase of the gait cycle, and is defined as the minimum vertical distance between the lowest point under the ... cited.Journal of NeuroEn gineerin g and Reha bilitatio n 2010, 7:18 JNER JOURNAL OF NEUROENGINEERING AND REHABILITATION Khandoker et al. Journal of NeuroEng...

Ngày tải lên: 19/06/2014, 08:20

... [32], resulting in the shut off of host protein synthesis. On the other hand, the function of L of the car- dioviruses is not well defined. L has been implicated in other functions of picornavi- ruses. ... findings are reminiscent of MS, that is, inflammatory cell infiltration and loss of myelin in the face of relative preservation of axons [1-4]. Ther...

Ngày tải lên: 19/06/2014, 22:20

... inflammation and demyelination (Fig. 2E). During the clinical remission phase (day 18), inflamma- tion and demyelination in the spinal cord were consider- ably diminished (Fig. 3G, 3I) and the number of infiltrating ... in combination with a lack of recruitment into the CNS late in the disease due to a decrease in the expression of chemokines and adhesion mol...

Ngày tải lên: 19/06/2014, 22:20

... Discussion and Evaluation: We assessed their innate and adaptive immune responses, by measuring the production of pro-inflammatory and counter-regulatory cytokines by peripheral blood mononuclear ... subjects, indicating the complexity of ASD pathogenesis and the need for careful evaluation of the use of IVIG in ASD children, other than for antibody deficiency syn...

Ngày tải lên: 19/06/2014, 22:20