... accumulation in these cells,through the uptake of oxLDL/LDL, is believed to be of fundamental importance to the etiology and pathogenesis of atherogenesis and atherosclerosis and other chronicinflammatory ... with the RNA Nano-chip (Agilent), using the RIN (RNA Integrity Number) algorithm [30] providedwith the instrument software. For these samples, the meanRIN ranged from 4.1–8.8, with a mean RIN of ... clearance.Finally, to determine whether the in vivo elevation of ABCA1 and ABCG1 mRNAs reflected the potency of ago-nists to activate LXR receptors, rats were treated with arange of doses of GW3965 (Figure...