... 2Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland, 3Division of Hematology and Transplant, Department of Clinical Medicine and ... end of the signaling response[120]. Expression of ZAP-70, which can enhance and pro- long on syk and other downstream signaling molecules,can partially determine the different capability of ... use for CLL patients of Natalizumab (TYSABRI, Biogen Idec, Cambridge, MA andElan Pharmaceuticals, South San Francisco, CA, USA), ahumanized anti-CD49d monoclonal antibody alreadyavailable and...