báo cáo hóa học: " Pilose antler polypeptides promote chondrocyte proliferation via the tyrosine kinase signaling pathway" pdf
Báo cáo hóa học: " Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinom" pot
... hyper- phosphorylation by mTOR [11,12]. To further clarify the signaling pathways regulated by LMP1 in NPC, we investigated the association between the mTOR signaling pathway and LMP1, the expression of p-mTOR, ... well-known oncogene, one of the functions of LMP1 is to promote cell proliferation in NPC [24,25]. The mTOR signaling pathway is also a major effector in cell...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học:" Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin" docx
... the time of presen- tation to the first biopsy. Therefore, chemotherapy treat- ment is a necessary ancillary method for these NPC patients [2-4]. Of all the chemotherapy drugs, cisplatin is the ... protein has the capacity to drive cisplatin out of the CNE2 cells. ABCC2 siRNA increased the sensitivity of cisplatin in CNE2 cells without changing the cell viability To assess t...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis" docx
... to ICAM-1 provided by tumor-activated hepatic cells. There- fore, the microenvironment created by the 3D-growth of cancer cells may per se promote the transition from avas- cular to vascular stage ... enhanced the adhe- sion of CT26 to ICAM-1-expressing angiogenic hepatic myofibroblasts and endothelial cells; and endowed CT26 cells with the capability to further increase VEGF secr...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Isolation and culture of fibroblasts from endoscopic duodenal biopsies of celiac patients" pdf
... manual management of the endoscope and endoscopic forceps, and their passage through the endoscopic channel together with the patients' gastric juice and saliva. For these reasons we used a ... described could help in the establishment of novel experiments to study the role of FBs in the pathogenesis of the mucosal damage and to test new therapies alternative to the glute...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
... com- pared the permeability of the BTB of RG-2 gliomas grown within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis skeletal muscle, the ... of an increase in the physiologic upper limit of pore size in the barrier due to the disruption of the glycocalyx layer. The damage that occurs to the glycocalyx of...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx
... inter- preted the immunoassay and drafted portions of the man- uscript describing the assays. WG participated in the design of the study and performed the statistical analysis. AK participated in the study ... staining characteristics of the tumor cells suggest that the EMD 273063 immunocytokine had gained access to the tumor milieu. Although the choice of biopsy site an...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... Therefore, the waning of Treg cells, and ensuing breakdown in the self tolerance, could depend on the in situ IL-2 environment. These data all together suggest that Treg cell stabilit y and their ... alleles [22]. The protection conferred by the Idd3 C57BL/6 allele can be explained by the pre- sence of 46 SNPs upstream of the minimal promoter of the IL-2 gene that can alter t...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... different yet complementary hypothesis based primarily on the systematic analysis of DNA vac- cines as priming agents. This hypothesis relies on the finding that during the initiation of immune response, ... lead the field, while many synthetic and viral vector approach es are in clinical developmen t [6,7]. Nevertheless, homologous prime-boost approaches for the prophylaxis of HIV,...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages" pdf
... contain exosomes [8,12,15], the aims of the current study were to determine whether these exosomes contain RNA and whether they can be taken up by other cells, which would support the concept that shuttling ... befo re being added to the exosomes and the control. The sam- ples were mixed gently for 4 min before 2 ml of 1% BSA was added to bind the excess dye. The samples were...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " Validation of a short form Wisconsin Upper Respiratory Symptom Survey (WURSS-21)" pdf
... enrollment. Half the sample filled out the WURSS-21 in the morning and the WURSS-44 in the evening; the other half com- pleted the questionnaires in reverse order. In addition to the WURSS-21 and ... of illness. Half the sample filled out the WURSS- 21 in the morning and the WURSS-44 in the evening, with the other half reversing the daily order. External comparat...
Ngày tải lên: 18/06/2014, 19:20