... Treatment of Cancer QLQ-C30: a quality -of- life instrument for use in international clin-ical trials in oncology. J Natl Cancer Inst 1993, 85(5):365-376.30. Bottomley A, Aaronson NK: International ... Classifying patients into subgroupsChange scores on global health of the EORTC QLQ-C30were used to identify subgroups of patients. In an analysis of the clinical significance of changes in HRQoL, ... and growing body of literature regarding theusefulness of the EQ-5D in cancer has emerged, support-ing its validity and reliability [19]. However, the respon-siveness of the EQ-5D, defined as...