... dasatinib in combination with chemother- apy was examined in the three dasatinib responsive cell lines, Lox-IMVI, HT144 and Malme-3M and in one of the dasatinib-resistant cell lines, Sk-Mel-28. In ... clinical trials of dasatinib in melanoma are currently underway, including a phase I/II study of dasatinib in combination with dacarbazine http://www.clinicaltri als.gov. Conclusion...
Ngày tải lên: 18/06/2014, 15:20
... S-adenosyl methionine domain containing 2 SAMD9 3.8 2.1 3.3 2.6 2.1 2.1 2.0 sterile alpha motif domain containing 9 SERPING1 4.9 1.9 4.1 2.3 1.9 2.0 2.1 serpin peptidase inhibitor, clade G (C1 inhibitor), ... lectin 1, sialoadhesin 15.7 27.1 CCL2 216598_s_at chemokine (C-C motif) ligand 2 15.1 13.4 RSAD2 213797_at radical S-adenosyl methionine domain containing 2 11.7 12.8 IFIT1 203153_at int...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology" pot
... ELIS- POT, intra-cellular cytokine staining and major histocom- patiblity multimer staining [45]. Understanding the cryobiology principles that explain cellular function after preservation is becoming ... Foster M, Martin B, Wang E, Smith K, Marin- cola FM: Forecasting the cytokine storm following systemic interleukin-2 administration. J Transl Med 2004, 2:17. 115. Rossi L, Martin B, Hortin...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" The "Excellence in Translational Medicine" and "Bedside-to-Bench" Awards 2007–08" doc
... number or inhibiting their effector functions intuitively has the potential of increasing the efficacy of anti-tumour immunity. While increasing pre- clinical data support this hypothesis, appropriate ... unan- swered issues in this emerging basic and clinical research area in animal models and man toward delineating, e.g., the relative effects of T cells and depletion of Tregs. In the...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Evolutionary concepts in biobanking - the BC BioLibrary" docx
... for biospecimens is resulting in the transformation of biobanking from an immature 'cottage industry' con- ducted by individuals, into a complex institutional activ- ity [5,6]. Biobanking has expanded ... biobanks are often limited in their capacity and ability to ensure quality in the face of increasing demand. Our strategy to enhance both capacity and quality in research b...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Plasma cytokines in women with chronic fatigue syndrome" doc
... surfaces (e.g., skin, lining of the intestine) against bacteria, and plays a critical role in chronic intestinal inflammation [24,25]. The unchanged IL-17 and IL-23 levels in CFS noted in this study ... evaluation tool in Clinical Med- icine. Clin Chem 1993, 39:561-577. 23. Waldmann TA: The biology of interleukin-2 and interleukin- 15: implications for cancer therapy and vaccine desig...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Inflammatory mechanisms in ischemic stroke: therapeutic approaches" potx
... regulating the innate and adap- tive immune systems. Cytokines are thus upregulated in the brain in a variety of diseases, including stroke. In the brain, cytokines are expressed not only in the ... area of research in translational medicine. Cytokines and brain inflammation Cytokines are a group of small glycoproteins that are pro- duced in response to an antigen and were origina...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: "Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders" pptx
... Exp Med 1989, 170:827-845. 42. Kubin M, Kamoun M, Trinchieri G: Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. ... circulating APC populations. Cytokine production in VK3-20-loaded PBMCs In order to evaluate the impact of the VK3-20 protein stimulation on the production of cytokines involved in Table 1 C...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: "Genomic aberrations in borderline ovarian tumors" doc
... rominently in both overt carcinomas [37,50] and in the present series (the gains were found in 5 of 5 cases with bilateral borderl ine tumors and in 4 of 6 informative unilateral tumors showing ... and clinical information. SH participated in the design and coordination of the study and critically revised the manuscript. All authors read and approved the final manuscript. Competing...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor), ... National Cancer Institute. Using a reverse-phase pro- tein microarray assay, we determined molecular changes in 77 protein biomarkers in an oncrasin-sensitive lung cancer cell line after trea...
Ngày tải lên: 18/06/2014, 16:20