báo cáo hóa học: " Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice" docx

... histopathology Hematoxylin and Eosin staining was performed. Double Immunostaining was used to detect astrocytes and T-cells. In brief, sections were washed in PBS, followed by rinsing in PBS-0.5% Triton ... findings point to IRF7 as a key signaling intermediate in modulation of autoimmune demyelinating disease, and open the possibility that innate signals may also be protectiv...

Ngày tải lên: 19/06/2014, 22:20

... anti- inflammatory role of Akt in mouse macrophages has been most convincingly demonstrated in a study in which Akt1-deficient mice injected with LPS showed increases in proinflammatory 36 Table ... activation of the innate immune signaling pathways including the production of IFNβ [15]. Interferon regulatory factor 3 (IRF3) is a 53 kDa transcription factor crucial in...

Ngày tải lên: 19/06/2014, 22:20

... with their inpatient stay in gen- eral. In addition, the information obtained from the study could be used at decision-making level for implementing new strategies for structural changes in the Bulgarian ... by using, for the first time in Bulgaria, internationally accepted methods and were able to demonstrate that a measurement of inpatient satisfaction is indeed possible in Bulgar...

Ngày tải lên: 18/06/2014, 19:20

... titers for nasal turbinates, brain, spinal cord, muscle, and serum were in agreement with findings in Figure 2 (data not shown). Histopathologic lesions in the brain (including areas of the olfactory ... brain, and spinal cord. Respiratory tissue, includ- ing lung and nasal turbinates, contained virus following inoculation with 100 or 1 LD 50 beginning on days 1 and 2, respectively. CN...

Ngày tải lên: 20/06/2014, 01:20

... PrP protein (HuPrP82-146) corresponding to a PrP fragment found in certain prion-infected human brains [10], a control peptide containing the same amino acids in a scrambled order (HuPrP82-146scrambled) ... that occurs in AD has been mod- elled in vitro by incubating neurons with specific peptides derived from the amyloid-β protein [4]. The neuronal injury induced by these peptides in...

Ngày tải lên: 19/06/2014, 22:20

... to inward trafficking of various molecules and cells in the intravascular compart- ment. 2 Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interferon- γ (IFN-γ) induce opening and ... role in cell adhesion, i.e. slowing and initiating cell rolling, they have been shown to have a dominant role in allowing non-spe- cifically activated cells to gain access to the CNS [...

Ngày tải lên: 19/06/2014, 22:20

... Vazquez N, Donnelly RP, Larner AC, Finbloom DS: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Blood ... Letterio JJ, Gorham JD: TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphat...

Ngày tải lên: 20/06/2014, 03:20

... the intronic regions (Table 1). Oligo probes were designed in variable size (from 18 nucleotide to 25) to maintain constant the melting tem- perature [10-12]. In addition, 38 exonic and 31 intronic oligo-probes ... alternative screening methods were as time- and cost-intensive as direct sequencing, but did not provide the same definitive information. In addition, many of these methods c...

Ngày tải lên: 18/06/2014, 15:20

... medulloblastoma cell lines were maintained at 37°C in a humidified atmosphere contain- ing 5% CO 2 in RPMI media supplemented with 10% Fetal bovine serum, 2 mM L-glutamine, 1 mM 2-mercaptoetha- nol, ... DakoCytomation, Carpinteria, CA). Slides were blocked with biotin (Biotin Blocking System, Dako- Cytomation) and processed using the 3-step streptavidin- biotin-immunoperoxidase staining s...

Ngày tải lên: 18/06/2014, 15:20