báo cáo hóa học: " Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis" pot

... 8:161 http://www.jneuroinflammation.com/content/8/1/161 Page 7 of 9 RESEARCH Open Access Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis Til ... C, Schubart AS, Linington C: Commentary: Sorting the wheat from the chaff: identifying demyelinating components of the my...

Ngày tải lên: 19/06/2014, 22:20

... TLR9-dependent and -independent pathways are involved in IFN-α pro- duction in HSV infection [17]. In interferon-producing cells (IPCs) the MyD88-dependent pathway in TLR9 sign- aling mediates the secretion of ... protein inducing IFN-β (TRIF) leading to IRF-3 or NF-κB activation [2]. The interaction of TRIF and non- canonical IκB kinases IKKε and TANK-binding kinase 1 (TBK1) le...

Ngày tải lên: 20/06/2014, 01:20

... Nevertheless, since no relations have been found between neopterin and clinical progression, there are issues regarding the use of neopterin as a measure of the clinical efficacy of IFNb. It is ... Silvia Marino 3 , Valentina Zipoli 4 , Marino Zorzon 8 and Enrico Millefiorini 11 Background: Increased synthesis of neopterin and degradation of tryptophan to kynurenine, measured as k...

Ngày tải lên: 20/06/2014, 03:20

... removed from the training set. The other samples are reduced to those 50 genes with the highest signal-to-noise ratio, which are used as a training set in a training series. A training series generates ... spreading. The extracellular cell matrix receptors integrin alpha-3 and integrin beta-2 as well as the collagen binding protein-1 (SERPHINH1) were upregulated in AC. These genes hav...

Ngày tải lên: 18/06/2014, 15:20

... with a poor clinical outcome in CLL [2-8]. In the present review, the main factors playing a role in defining the biological features of CLL cells, hence eventu- ally influencing the clinical aggressiveness ... permits the develop- ment of a more specific antigen-binding site by maintain- ing the necessary supporting scaffold of BCR [6,72-76]. From a clinical point of view, in...

Ngày tải lên: 18/06/2014, 15:20

... local wound infection rates reflected overall infection rates of this group of patients. The baseline char- acteristics of the both patient groups are outlined in Table 1. The mean age of healthy ... patients at risk of dying. List of Abbreviations AP-1: Activator protein-1; CI: Confidence interval; ICU: Intensive care unit; IL-6: Interleukin-6; MIF: Macrophage migration inhib...

Ngày tải lên: 18/06/2014, 15:20

... IRAK4-kinase-dead knock -in mic e also fail, in vitro and in vivo,toproduce inflammatory cytokines in response to LPS and are pro- tected against LPS-induced sepsis in vivo [1 9,22-24]. There is, however, a resounding ... demonstrated that innate defence regulator peptides, which s uppress pro-inflammatory cytokines but substantially maintain chemokine responses, are able to pro...

Ngày tải lên: 18/06/2014, 16:20

... nature of the presenting symptoms or to poor physician awareness of PSS in general and confirms that, despite a growing quantity of research regarding the sever- ity of sicca symptoms and range of ... sicca. The domain scores, including somatic and mental fatigue domains, may be used independently or combined into a composite fatigue score (ProF), or further summarized to indices...

Ngày tải lên: 18/06/2014, 18:20

... health-related quality of life. HRQOL is defined as the perception of overall satisfaction with life and involves the measurement of functional sta- tus in the domains of physical, cognitive, ... important in defining health benefits? Med Sci Sports Exerc 2001, 33:379-99. 7. Ware JE, Kosinski M, Keller SD: A 12-Item Short-Form Health Survey: construction of scales and preliminar...

Ngày tải lên: 18/06/2014, 18:20

... developed, they are often tested in clinical tri- als against current treatment options. Clinical trial-based evaluations of treatments in many fields, including cardiology, often include cost-effective- ness, ... considered clinically significant [26]. In this study we assessed the change in EQ-5D index for a ten year increase in age, males versus females, a one minute increase...

Ngày tải lên: 18/06/2014, 19:20