báo cáo hóa học: " Sinomenine inhibits microglial activation by Ab and confers neuroprotection" doc

... Shukla and Sharma: Sinomenine inhibits microglial activation by Ab and confers neuroprotection. Journal of Neuroinflammation 2011 8:117. Submit your next manuscript to BioMed Central and take ... 8:117 http://www.jneuroinflammation.com/content/8/1/117 Page 6 of 11 RESEARC H Open Access Sinomenine inhibits microglial activation by Ab and confers neuroprotect...

Ngày tải lên: 19/06/2014, 22:20

... normal esophagus and ESCC, and in the tumor-associated stroma and tumor epithelium in one sample after laser capture microdissection (LCM). MMP-3 and MMP-10 transcripts in both the epithelium and stroma ... tumors and/ or new strategies for early detection and treatment of precursor lesions and early cancers. Endoscopy with iodine staining is a n accurate way to identify and...

Ngày tải lên: 18/06/2014, 16:20

... Sandvig K: Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases. Mol Biol Cell 2001, 12(7):2099-2107. 70. Grimmer S, Iversen TG, van Deurs B, Sandvig ... GTPase Rab9 and operates from late endo- somes (LE) [61]. The other is Rab9-independent and leads from an early endosomal (EE) compartment [17] These pathways also depend on separate vesi...

Ngày tải lên: 20/06/2014, 01:20

... first suggested by two laboratories in both, TMEV-IDD and EAE models by using the synthetic agonist WIN 55,212-2 [21,23]. In the present study we show that the endocannabinoid, AEA inhibits the ... [13,18,49,50] the role of endocannabinoids in MS remains uncertain. While most of studies on ECS and MS focused on established disease, understanding the role of endocannabinoids during t...

Ngày tải lên: 19/06/2014, 22:20

... [8]; and in macrophages may include activation of other kinases Inhibitory Effects of NE are mediated by β-ARs and replicated by cAMPFigure 4 Inhibitory Effects of NE are mediated by β-ARs and ... are mediated by β 2-ARs and may involve cAMP The inhibition of nitrite accumulation by NE was mim- icked by the β-AR agonist isoproterenol used between 0.1 and 10 µM (Figure...

Ngày tải lên: 19/06/2014, 22:20

... (1:25) and rabbit-anti-human GFAP (Sigma, Saint Louis, USA; 1:400) with 0.5% goat serum and 0.1% triton X-100, followed by secondary antibodies goat-anti-mouse FITC 1:200 and goat-anti-rabbit ... Corresponding author Abstract Based on their potent anti-inflammatory properties and a preliminary clinical trial, statins (HMG- CoA reductase inhibitors) are being studied as possible can...

Ngày tải lên: 19/06/2014, 22:20

... mAb D3 against nucleolin. After washing, cells were fixed with 3.7% PFA and washed again, and the primary anti-PTN antibody was revealed by FITC-conjugated rabbit anti-(goat IgG) Ig, whereas mAb ... decreased by 50 and 80% in CHO 677 and CHO 618 cells, respectively (Fig. 3). This decrease is probably due to the lack of heparan sulfate and heparan ⁄ chondroitin sulfate proteoglyca...

Ngày tải lên: 30/03/2014, 20:20

... Sarcoma viral oncogene homolog 0.46 0.37 RABL2B Rab-like 2B 0.35 0.37 RABL2A Rab-like 2A 0.33 1.34 SCC = squamous cell carcinomas, NT = normal lung tissue Table 3: Selection of significantly differentially ... NT and SCLC vs. NT was 2.2, 2.1 and 3.2-fold, respectively); collagen, type I, alpha 1 (overexpression in AC vs. NT, SCC vs. NT and SCLC vs. NT was 7.98, 3.24 and 2.4-fold, res...

Ngày tải lên: 18/06/2014, 15:20

... washed, and Ca 2+ free buffer containing IgG (panel A), the CD66ae mAb and CD66b mAb (panel B), the CD66ae mAb and CD66c mAb (panel C), the CD66ae mAb and CD66de mAb (panel D), the CD66b mAb and ... to stimulation by the CD66ae, CD66b, and CD66de mAbs desensitized the cells to further stimula- tion by the CD66c mAb, as well as CD66ae, CD66b, and CD66de mAbs, but not by C...

Ngày tải lên: 18/06/2014, 15:20

... contributions FS, and AS have made substantial contribution in the acquisition and alignment of sequences, in the analysis and interpretation of data, and helped to draft the manu- script. LC, BP, PGN, and ... limitations imposed by the limited number of patients analyzed and by the fact that the mature TR rep- ertoire is influenced not only by the coding potential of TR VDJ...

Ngày tải lên: 18/06/2014, 15:20