báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx

... 14 REVIE W Open Access Wallerian degeneration: the innate-immune response to traumatic nerve injury Shlomo Rotshenker Abstract Traumatic injury to peripheral nerves results in the loss of neural ... Further, cytokines may be divided into major classes. Inflammatory cytokines (e.g. TNFa,IL-1a,andIL-1b; also referred to as pro- inflammatory) promote the production of i...

Ngày tải lên: 19/06/2014, 22:20

... exiting the nerve by the circulation once remyelination has occurred. The efficacy of the PNS inflammatory response (although transient) stands in stark contrast with that of the CNS, where the response ... catastrophic granular disintegration of the cytos- keleton occurs [23,24]. Granular disintegration of the cytoskeleton - the sudd en destruction of cytoskeletal ele...

Ngày tải lên: 19/06/2014, 22:20

... Access Combination therapy: the next opportunity and challenge of medicine Paolo A Ascierto 1* and Francesco M Marincola 2 Abstract From an historical point of view, combination therapy was the basis for the ... diseases or cancer. Today the “cocktail drug” of the Highly Active Anti Retroviral Therapy (HAART) has reduced the death for HIV infection changing the outcome of such d...

Ngày tải lên: 20/06/2014, 04:20

... of the T cell receptor (TCR) to antigen bound within the major histocompatibility com- plex (MHC) presented by APCs; the second is the binding of costimulatory ligands, expressed on APC, to receptors on ... challenges to understand tumor immunology and leverage this knowledge towards improving the bio- logical therapy of cancer. The expected outcomes after the completion o...

Ngày tải lên: 18/06/2014, 15:20

... viability. Several hypotheses could be therefore assumed, one of which is that the compounds could act as cytotoxic and/or cytostatic agents. To test a hypothetical cytostatic activity of the selected ... [13]. The most accredited theory to explain the MPT is the opening of a multiprotein complex, the mitochondrial permeability transition pore (MPTP), located at the contact...

Ngày tải lên: 18/06/2014, 15:20

... field was largely in enhancing the effectiveness of methods to efficiently transfer knowl- edge from the bench to the bedside, and, importantly, from the bedside to the bench [2-4]. In particular, ... efficiency rather than modifying the process" [3]. We also argued, in response to editors and publishers of existing journals who questioned the need for yet another...

Ngày tải lên: 18/06/2014, 15:20

... [19]. To evaluate the effect of the calcipotriol ointment and BDP in this model, we tested the compounds topically and compared the results to the findings from the plaque test. The effect on the ... the back of the animals. The split human keratome biopsies were then grafted onto the back of the animals. The grafts were protected by a band- age during the fo...

Ngày tải lên: 18/06/2014, 15:20

... Rubinstein et al.: Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032. Journal of Translational ... clini- cal response to PLX4032, associated with substantial reductioninthetumorburdenandpainfromthe lesions. Figure 1 shows the cutaneous lesions before and after treatment with PLX...

Ngày tải lên: 18/06/2014, 16:20

... mA. The measured latency was the time span from the stimulation to the beginning of the first w ave, whereas the amplitude was thevoltagedifferencebetweenthepositiveandthe negative wave. The ... http://www.axon.com). The stimulating electrode and the reference electrode were placed in the median nerve of the muscles between the ulner and radical bone, and the pre...

Ngày tải lên: 18/06/2014, 16:20

... RBM3 led to a decreased cisplatin response in ovarian cancer cells. Taken together, these data demonstrate that RBM3 is a marker of good progn osis in EOC and a predictor of response to platinum-based ... sufficient evidence to support the hypothesis that, in addition to being a beneficial prognostic biomarker, RBM3 might also predict cisplatin response in EOC. Further studies...

Ngày tải lên: 18/06/2014, 16:20