... for evalua- tion of dasatinib in clinical trials in melanoma patients. Two clinical trials of dasatinib in melanoma are currently underway, including a phase I/II study of dasatinib in combination ... cell cycle arrest, apoptosis, migration and invasion in human melanoma cell lines. Expression and activation of Src kinase, FAK and EphA2 were also examined in...
Ngày tải lên: 18/06/2014, 15:20
... Translational Medicine Open Access Research Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood monocytes (PBMC) of hepatitis C patients during the first ... relapsed by the end of treatment. Changes in Global Gene Expression Gene expression in PBMC changed dramatically and rap- idly during PEG-in...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ-responsive genes" pptx
... purposes) Journal of Translational Medicine Open Access Research Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ- responsive genes Xie ... also contributed to TGFβ activation in glioblastomas. In addi- tion, genes involved in antigen presentation were upregu- lated in the...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology" pot
... for citation purposes) Journal of Translational Medicine Open Access Commentary Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology Hideaki ... participate in the workshop including the National Cancer Institute (NCI), the National Institutes of Health (NIH) Center for Human Immunology (CHI) and th...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" The "Excellence in Translational Medicine" and "Bedside-to-Bench" Awards 2007–08" doc
... tumour-associated antigens and thereby, represent a major obstacle to immunotherapy. Thus, reducing their number or inhibiting their effector functions intuitively has the potential of increasing the efficacy ... and man toward delineating, e.g., the relative effects of T cells and depletion of Tregs. In the process, the paper by Rasku et al. [5] exemplifies the jour- ney...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Evolutionary concepts in biobanking - the BC BioLibrary" docx
... streamline and improve biobanking activities; 4) the BC BioLibrary enhances qual- ity and accessibility of biospecimens; and 5) the BC BioLi- brary contributes to the sustainability of biobanking in ... data capture rel- evant to the BCU, the BCU inventory database ('BCU Cat- alogue'), as well as a web based training curriculum. The evolution from this single,...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Plasma cytokines in women with chronic fatigue syndrome" doc
... surfaces (e.g., skin, lining of the intestine) against bacteria, and plays a critical role in chronic intestinal inflammation [24,25]. The unchanged IL-17 and IL-23 levels in CFS noted in this study ... profiles of 16 plasma factors including the pro -inflammatory cytokines: tumor necrosis factor α (TNFα), lymphotoxin α (LTα), interleukin (IL) - IL-Iα, IL-1β, IL- 6; T H 1 cytokine...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Inflammatory mechanisms in ischemic stroke: therapeutic approaches" potx
... regulating the innate and adap- tive immune systems. Cytokines are thus upregulated in the brain in a variety of diseases, including stroke. In the brain, cytokines are expressed not only in the ... Pivotal role of cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury. Nat Med 2009, 15:946-950. 28. Barone FC, Feuerstein GZ: Inflammatory mediat...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: "Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders" pptx
... Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders. Journal of Translational Medicine 2010 8:18. Buonaguro et al. Journal of Translational Medicine ... Journal of Translational Medicine 2010, 8:18 http://www.translational-medicine.com/content/8/1/18 Page 4 of 11 RESEARC H Open Access Immune signatures in human...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " Complement activation in the Parkinson''''s disease substantia nigra: an immunocytochemical study" ppt
... staining in substantia nigra specimensFigure 2 C9 staining in substantia nigra specimens. Fig. 2A: Staining of multiple Lewy bodies within a melanized neuron in a PD specimen; adjacent melanized ... had few remaining melanin granules. No cellular staining was present in negative controls, although faint vascular stain- ing was observed in a few specimens. Staining for iC3b and...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Microglia activation in sepsis: a case-control study" ppt
... GJ, Plata-Salaman CR: Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain follow- ing intraperitoneal administration of bacterial lipopolysac- charide. Brain ... time in human brain tissue an association between a systemic infection and activation of microglia in the brain. Activated microglia during sepsis could play a role in behaviora...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Musculoskeletal disorders early diagnosis: A retrospective study in the occupational medicine setting" docx
... 6:1 http://www.occup-med.com/content/6/1/1 Page 3 of 6 CAS E REP O R T Open Access Musculoskeletal disorders early diagnosis: A retrospective study in the occupational medicine setting John Kulin 1*† , MaryRose Reaston 2† Abstract Electrodiagnostic ... of Labor and Occupational Safety and Health Administration (OSHA) define a musculoske- letal disorder (MSD) as an in...
Ngày tải lên: 20/06/2014, 00:20
Báo cáo hóa học: " Editorial Advances in Error Control Coding Techniques" ppt
... reproduction in any medium, provided the original work is properly cited. In the past decade, a significant progresshas been reported in the field of error control coding. In particular, the innovation ofturbo ... Hindawi Publishing Corporation EURASIP Journal on Wireless Communications and Networking Volume 2008, Article ID 574783, 3 pages doi:10.1155/2008/574783 Editorial Adva...
Ngày tải lên: 21/06/2014, 23:20
Báo cáo hóa học: " Detecting Impulses in Mechanical Signals by Wavelets" ppt
... the Institute of Vibra- tion Engineer ing in this university. He ma- jors in vibration analysis, dynamics, signal processing, and automatic control. Detecting Impulses in Mechanical Signals by ... Applied Signal Processing 2004:8, 1156–1162 c 2004 Hindawi Publishing Corporation Detecting Impulses in Mechanical Signals by Wavelets W X. Yang Institute of Vibration...
Ngày tải lên: 23/06/2014, 01:20
Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx
... exacerbate liver injury [9]. In addition to apoptosis, certain caspases, such as caspase-1, are involved in cytokine maturation by proteolytically proces- sing the inactive precursors of interleukin ... not apoptotic cells, is systemically elevated in human sepsis and functions as a mediator of endotoxin lethality in mice [12]. Intense research has recently delineated the sign...
Ngày tải lên: 13/08/2014, 18:22