... native, conformational antigenic epitopes of influenza proteins in the context of a highly immuno-genic, non-infectious structure. VLPs elicit immune responses and protection at low doses (HA content) ... protection. Protectionagainst influenza infection is a multifactorial phenome-non, with both innate and cellular responses (NK, NKT,and CD8+ T cell responses) associated with clearance of influenza ... [2-4,11].Conventional seasonal influenza vaccines use a trivalentmixture of split viruses, containing two influenza A sub-types (H1N1 and H3N2) and one variant of influenza Bvirus without the loss of...