báo cáo hóa học: " Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid" pdf
báo cáo hóa học: " Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid" pdf
... Central Page 1 of 9 (page number not for citation purposes) Journal of Neuroinflammation Open Access Research Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal ... knockout (IL1raKO) mice, which have enhanced IL -1 signaling because of the loss of the IL -1 receptor& apos;s physiological antagonist. We...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy" pot
... -/- APP/IL-1R1+/- 6M Age of mice (Months) 500 15 00 2500 3500 15 M9M Tg2576 (IL-1R1+/+) SDS 40 (pM/g) 0 10 0 200 APP/IL-1R1 -/- APP/IL-1R1+/- 6M Age of mice (Months) 500 15 00 2500 3500 15 M 9M Tg2576 (IL-1R1+/+) FA42 ... fractions of Aβ40 and Aβ42 were measured by capture ELISA. 0 50 10 0 APP/IL-1R1 -/- APP/IL-1R1+/- 6M Age of mice (Months) 15 0 350 550 15 M 9M Tg2...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat" potx
... mg/kg (n = 7) 54.9 ± 14 .9 38 .1 ± 17 .2 14 .3 ± 2.4 Nimesulide 6 mg/kg (n = 8) 41. 4 ± 12 .3 31. 8 ± 9.3 9.7 ± 3.5 Nimesulide 12 mg/kg (n = 9) 34 .1 ± 13 .8 ** 24.6 ± 11 .2 ** 7 .1 ± 3.9 * Single dose Vehicle, ... (n = 7) 55.2 ± 15 .5 43.9 ± 10 .9 13 .2 ± 4.2 Nimesulide 12 mg/kg, single dose (n = 8) 49.5 ± 11 .7 39.4 ± 11 .8 9 .1 ± 3 .1 & Data are mean ± S.D. * P <...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Interleukin-1 mediates Alzheimer and Lewy body pathologies" potx
... WS: S100 β increases levels of β-amyloid precursor protein and its encoding mRNA in rat neuronal cultures. J Neurochem 19 98, 71: 14 21- 1428. 20. Barger SW, Harmon AD: Microglial activation by Alzheimer amyloid ... elevate neuronal synthesis of βAPP and release of sAPP and increase levels of α-synuclein and phosphor- ylated-tau; microglial release of IL -1 app...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Interleukin-1β and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes" potx
... Brain interleukin 1 and S -10 0 immunoreactiv- ity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 19 89, 86:7 611 -7 615 . 19 . Rothwell NJ: Functions and mechanisms of interleukin ... neurotrans- metters and cytokines [12 -14 ]. IL -1 is one of the most potent stimulators of NGF secretion in cultured neonatal astrocytes [15 ,16 ,14 ]. In nor...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro" pot
... 19 90, 11 7(3):335-340. 63. Ho A, Blum M: Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin- 1 beta in the striatum of young and middle-aged mice. Exp Neurol 19 97, ... CW: Interleukin- 1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain research 2008, 11 88 :18 9 -19 7. 18 . Hendrix S, Peter...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf
... the IL -1 receptor antagonist (IL-1Ra) is protective in experimental models of stroke [1] , and has shown promise as a treatment in clinical trials [2]. Mice in which both IL -1 and IL -1 have ... Kovacs KJ: Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse. J Cereb Blood Flow Metab 2008, 28 :17 07 -...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo hóa học: " Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade" pot
... residues in the PB1 genes. Interestingly, compared with the sequence of the PB1 of A/Vietnam /12 03/04, that of H3N2-PB1 differs by only 21 residues, while that of the H1N1-PB1 differs by 34. Furthermore, ... in pHW72-EGFP substituted with luciferase gene [30] and a mix of PB2 (1 μg), PB1 (1 μg), PA (1 μg), and NP (2 μg) plasmids of A/HK/ 218 847/06 (H1N1) and A/HK/...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo hóa học: " Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1" pptx
... 11 8 HIV -1- infected and 18 2 HIV- 1- uninfected, the infection was confirmed by disease onset and/ or persistence of HIV -1 antibody after 18 months of age, while lack of infection was confirmed by the ... 0.48 0.38 0.62 0.37 1. 06 GG 0. 21 0.23 0.86 0.46 1. 62 Haplotypes G;A 0.53 0. 51 1 A;G 0.44 0.36 0.92 0.65 1. 30 0.63* A;A 0.02 0.07 3 .16 1. 24 8.03 0. 016 * G;...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học:" Sphingosine-1 phosphate receptor (S1p1), a critical receptor controlling human lymphocyte trafficking, is expressed in hen and human ovaries and ovarian tumors" ppt
... trafficking, activation of S1P1 can promote or inhibit apoptosis of immune cells depending on the balance of cytokines [7]. Knockout of S1P1 (LP( B1)/ EDG -1) in mice is embryologi cally lethal [8]. S1P1 ... used to detect S1P1 mRNA and an anti -human S1P1 antibody was used to detect S1P1 protein, the expression of S1P1 mRNA and protein were correlated. Similarly, S1P1 wa...
Ngày tải lên: 20/06/2014, 07:20