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báo cáo hóa học: " Vascular consequences of passive Aβ immunization for Alzheimer''''''''s disease Is avoidance of "malactivation" of microglia enough?" docx

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báo cáo hóa học: " Vascular consequences of passive immunization for Alzheimer''''s disease. Is avoidance of "malactivation" of microglia enough?" docx

... AccessCommentary Vascular consequences of passive immunization for Alzheimer's disease. Is avoidance of "malactivation" of microglia enough?Steven W Barger*1,2,3Address: 1Department of ... [19] – and a vascular accumu-lation of CD45+ cells presumed to be microglia. The exper-imental paradigm was one of passive immunization of transgenic mice at nearly two years of age, old enough ... antibodiesrecognizing Aβ, either by active vaccination or by passive immunization (injection of antibodies, typically mono-clonal), results in removal of some deposits and/orprevention of their formation....
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báo cáo hóa học: " Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients" pot

... contributionsPKG Acquisition of data and writing of manuscript. SP inclusion of patients,grant PI and clinical scoring. CA Acquisition of data. NKS Statistical analysis.AA Interpretation and analysis of data, ... test analysis showed that mean agediffer significantly among the groups (p = 0.004). ‡ Duration of disease is the interval between appearance of first symptom of ALS and collection of sample. ... student t test and one-way analysis of variance(ANOVA) followed by Fisher’s least significant differ-ence (LSD) post hoc analysis w as applied for statisticalcomparisons. Crude and adjusted odds...
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báo cáo hóa học:" Viral load testing in a resource-limited setting: quality control is critical" potx

... monitoring allows for evaluation of disease progression [4], and VL testi ngcan increase adherence and facilitate timely switching of failing regimens, minimizing the development of resis-tance [5]. ... jane.greig@london.msf.org1Manson Unit, Médecins Sans Frontières, London, UKFull list of author information is available at the end of the articleGreig et al. Journal of the International AIDS Society 2011, 14:23http://www.jiasociety.org/content/14/1/23© ... resistance.Retes ting patient s because of quality control problemswas a burden for them and for programme staff, espe-cially as some patients had to be reca lled to discussTable 1 Results of...
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báo cáo hóa học:

báo cáo hóa học: " Clinical consequences of asbestos-related diffuse pleural thickening: A review" pptx

... howeversimilar for the detection of pleural plaques and CT wassuperior for the detection of pleural calcification which is a marker of benign disease. PET can help distinguish between malignant ... highlyeffective for patients with pleural disease due to othercauses. This has not, however, been formally studied for asbestos-related DPT.ConclusionDPT is now a well recognised consequence of asbestosexposure ... radiol-ogy and prognosis. Treatment is largely limited tosupportive and symptomatic care. The incidence of this disease is currently rising and total numbers are likely toexceed those of malignant mesothelioma...
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báo cáo hóa học: " Population norms and cut-off-points for suboptimal health related quality of life in two generic measures for adolescents: the Spanish VSP-A and KINDL-R" pdf

... case of theSDQ and by adolescents in the case of socio-demograph-ical variables, Oslo Scale, and presence of a chronic condi-tion.Statistical analysisDescriptive statistics of the Spanish ... cut-off points for groups with more impairedHRQL. Generally, the selection is made in terms of thedistribution deciding which proportion of the populationwould be in the group of ill health. For ... [11]. As part of the proc-ess of obtaining the Spanish versions, interpretabilityissues were defined. The aims of this study were to facili-tate the interpretation of the Spanish VSP-A and...
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Báo cáo hóa học: " The transfer from survey (map-like) to route representations into Virtual Reality Mazes: effect of age and cerebral lesion" doc

... the VE a nd withthe use of keyboard for movement. This was accom-plished with a n initial period of experimenter instruc-tion, followed by a period of free exploration of a VEusing the keyboard. ... topographi-cal information are, respectively, named “survey” and* Correspondence: marialuisa.rusconi@unibg.it1Department of Human Science, University of Bergamo, Bergamo, ItalyFull list of author information ... representations exist in paralleland are joined to support behaviour according to thetask [4]. An example of this relation is represented bythe typical situat ion of a tourist with a map of a townhe/she’s...
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báo cáo hóa học: " Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice" ppt

... immunohistochemistry and ELISAs,and guided or performed image analysis, analyzed dataand drafted the manuscript. LJ performed tissue prepara-tion, immunohistochemistry, image analysisand ELISAs.KT ... studies, Aβ1 –40, Aβ1 –42, Aβ1 –15 and dAβ1–15, were synthesized by the BiopolymerLaboratory, Center for Neurologic Diseases (Boston, MA). Aβ1 –15 peptide is a single copy of the first 15 amino acids of ... tissue was harvested, immunohistochemistry performed and computer assisted quantification completed. J20 APP-tg mice primed with an injection of Aβ1 –40/42 and boosted with Aβ1 –40/42 or dAβ1–15...
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báo cáo hóa học: " Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study" pdf

... [20,21]. This may, in part, berelated to the formation of anti-interferon beta neutraliz-ing antibodies [22]. In an effort to address this issue, interms of a marker of response, levels of interferon ... measurement of sHLA in CSF wouldbe most likely to reflect CNS disease activity. Measure-ment of such a biological marker of disease activity couldpotentially serve as a monitor of response ... con-centrations of sHLA-I and sHLA-II in their serum [1].However, the serum level of sHLA-I is significantly ele-vated in patients with various inflammatory diseases [5-8]although this is not necessarily...
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báo cáo hóa học: " Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease" pdf

... majority of studies focus on the effects of air pollution in cardiovascular and pulmonary disease [12], accumulating evidence now points to a new role for air pollution in CNS disease [10]. For example,human ... multiplicationanalysis in Italian familial Parkinson disease. Parkinsonism Relat Disord2010, 16:228-231.40. Chiba-Falek O, Lopez GJ, Nussbaum RL: Levels of alpha-synuclein mRNA insporadic Parkinson disease ... neuroinflammation asan active participant in the progression of neurodegen-erative diseases, such as Parkinson’sdisease(PD)andAlzheimer’s disease (AD) [1-3]. In fact, current theor yholds that pro-inflammatory...
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