... population, and the expression of inflammatory mediators is highly variable and not onlydependent on the source of sepsis but also on the geneticmake up of the host, which defines the immune response[17]. ... levels in the peripheral blood, which is the morecommon way to stu dy the immune r esponse to sepsis. The levels and dynamics of these mediators correlate withoutcome [18-20]. One of the main ... in the periph-eral blood is that only the endocrine overflow is measured,not the local autocrine and paracrine receptor binding effects [10,11]. On the other hand, measuring expression of the...