... orchestrating an antitumorimmune response. The main finding of this study was anincrease in intratumoral CD8+ CTL with possibleincreased expression of CD3zeta and granzyme B afteradministration of ... approximately15% in patients with metastatic melanoma, with nearlyhalf of these responses being extremely durable and lead-ing to a seemingly cured subset of patients [1,2]. The maindrawback of IL2 therapy ... metastatic melanomaand renal cell carcinoma. J Immunother 2003, 26:130-138.13. Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, SatoN, Kaiser A, Hinrichs CS, Klebanoff CA, Tagaya Y, Restifo...