... within 6 h of treatment (Fig. 4C,D).IL-1β induces α-synuclein in vivoWe next sought to extend our in vitro findings regardingIL-1-induced elevation of α-synuclein and of other pro-teins ... Neurobiol Aging 2005, 26:349-354.6. Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, WhiteCLd, Araoz C: Brain interleukin 1 and S-100 immunoreactivityare elevated in Down syndrome and ... mechanisms in these diseases, previously assumed to be distinct. Glial activation, with overexpression ofinterleukin-1 (IL-1) and other proinflammatory cytokines, has been increasingly implicated in...