Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... CyP's capacity to impair innate resistance to HSV-1 [56,57]. Further study is needed to test thishypothesis. Role of Stat 1 in innate resistance to HSV-1 The biological functions of IFN-α/β and ... CentralPage 1 of 15(page number not for citation purposes)Virology JournalOpen AccessResearch Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1William ... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i. The following study was initiated to determine if NK cells provide innate...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... designed on the basis of side-chain packing criteriafrom a modelled structure of the enzyme resulted in restor-ation of the energy of activation to the levels of the nativeenzyme and in an increased ... doi:10.1046/j.1432-1033.2002.02895.xstrain TAB5. We particularly attempted to investigate the functional importance of the Gly pair, located in the vicinity of the active site of the cold adapted enzyme and to study itspotential role ... thuscompensating this increase in the side chain volume. The contribution of Gly clusters in the cold adaptation of enzymes was also examined in the case of the mammalianpsychrotolerant hormone-sensitive...
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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... number of test documents and find that the fea-ture vectors corresponding to some of these docu-ments (particularly the short ones) have all zeroes in them. In other words, none of the bigrams ... im-portantly, an analysis of these results show that the various types of features interact in an interestingmanner, allowing us to draw conclusions that pro-vide new insights into polarity classification.2 ... rating of ≤ 2 (out of 5)or ≤ 1.5 (out of 4).614Finally, previous work has also investigated fea-tures that do not fall into any of the above cate-gories. For instance, instead of representing...
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Báo cáo khoa học: Probing the determinants of coenzyme specificity in Peptostreptococcus asaccharolyticus glutamate dehydrogenase by site-directed mutagenesis potx
... with thesemutations binding of NADPH was still too weak to allow determination of a Kdvalue in the absence of the other substrate. In the presence of oxoglutarate,however, coenzyme binding ... NADH. Lysine is closer in size to the glutamate it replaces than arginine, and it is possiblethat the latter is too large to allow optimal orientation of the coenzyme. Although the binding of NADPH ... and thereforemeasurable and, in particular, gave measurable Kdvalues for binding of NADPH to both E243K andE243R, whereas the binding of NADH to thesemutants was too weak to measure, in keeping...
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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
... with the histidine residue of the H-loop, and positions the ‘linchpin’ histidine in the correct orientation such that all atoms are then in position to favor abstraction of a proton from the attacking ... proteins. To answer thisquestion, we took advantage of the trypsin-sensitiveregion situated in the linker domain of Abcb1a. Fol-lowing trapping in the absence or presence of Vi andmild-trypsin treatment, ... trapping isalmost normal. By contrast, when the charge isremoved, as in the glutamine (length of the side chainmaintained) and asparagine (shorter side chain)mutants, then trapping in the...
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Báo cáo khoa học: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo pptx
... FEBSDissecting the role of the N-terminal metal-bindingdomains in activating the yeast copper ATPase in vivoIsabelle Morin1,2,3,*, Simon Gudin1,2,3, Elisabeth Mintz1,2,3and Martine Cuillel1,2,31 ... the N-terminus of Ccc2is not only involved in receiving copper from Atx1,but also plays a crucial role in the overall function of the ATPase by delivering copper to another sitebelonging to ... informationabout the functionality of the ATPase, they are allinterpreted independently of the metallo-chaperone.Indeed, studying the Atx1–Ccc2 route in vivo remainschallenging, because of...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
... unsure of the mechanism of DNA-induced stabilization of the protein, and whe-ther it is related to the normal RNA-binding function of coat protein, as RNA binding had no effect. The increased ... understood, and we have investigated thesequestions in this work. We sought to determine the role of protein–RNA and protein–protein interactions in virus stability, measuring the effects of urea,GdnHCl ... a convenient means to monitor changes in protein conformation in the pres-ence of denaturing agents. The tryptophan residuesburied in the hydrophobic interior of the proteinemit fluorescence...
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Báo cáo khoa học: "Assessing the Role of Discourse References in Entailment Inference" pptx
... mandatory for inference. In another 28%,references could optionally support the inference of the hypothesis. In the remaining 28%, refer-ences did not contribute towards inference. The total ... enough;(3) the limitation to nominal coreference; and (4)overly simple integration of reference informationinto the inference engines. The goal of this paper is to assess the impact of discourse ... frameworkfor modeling semantic inference. TE reduces the inference requirements of many text understand-ing applications to the problem of determiningwhether the meaning of a given textual...
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Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx
... it to the flavin ring through the S80 side-chain [22]. Such observation also suggested that in E301A FNR the side-chain of E139 might in uence the properties of the flavin, assuming some of the ... conformational chan-ges in the side-chain of another glutamic acid residue, E139,that in the mutant points towards the FAD cofactor in the active centre cavity and is stabilized by a network of hydrogen ... decrease in the efficiency of the assay was observed upon increasing the ionic strength, which, as indicated above, is due mainly to the increases observed in the KNADPHmvalues.NADPH-dependent cytochrome...
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báo cáo hóa học:" A novel role of HLA class I in the pathology of medulloblastoma" docx
... of medulloblastoma cells in a wound scratch assay. DAOY cells were grown into near confluence when a wound wascreated in the center of the monolayer, and the ability of neighboring cells to migrate into the ... capability of medulloblastoma cells. In summary, we found a novel role of MHC class I con-tributing towards a more malignant phenotype of medul-loblastoma by enhancing the activation of ERK1/2. The contrasting ... due to binding of distinct regulatory subunits [61]. Thus, the exact mecha-nism of HLA class I open conformer engagement-medi-ated activation of ERK1/2 in medulloblastoma remains to be determined.Dysregulation...
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