... purposes)Virology JournalOpen AccessMethodology Stereophysicochemical variability plots highlight conserved antigenic areas in FlavivirusesCatherine H Schein*1,3, Bin Zhou1 and Werner Braun1,2Address: ... dimension to structurally defining the binding sites ofneutralizing antibodies. They provide a useful aid for determining antigenically important regionsand designing vaccines.BackgroundFlaviviruses, ... amino acid substitutions,to determine areas of residue conservation in proteins.Our program suite, PCPMer http://129.109.59.110/BinZhou/PCPMer/index.html, defines areas of conserva-tion in...