Báo cáo sinh học: " Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas" potx
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... hypoxia. Experimental procedures Cell culture and hypoxia study The human cell lines used were KG1 myeloid cells, K562 erythroid cells, and Jurkat T-lymphocyte cells and were maintained in RPMI-1 640 medium (Sigma, ... erythroid cells [27, 34] were maintained in Iscove’s Modified Dulbecco’s Medium (IMDM) (Sigma). HeLa and HepG2 cells were maintained in DMEM. Each medium conta...
Ngày tải lên: 19/02/2014, 06:20
Báo cáo khoa học: Stimulation of fibroblast proliferation by neokyotorphin requires Ca2+ influx and activation of PKA, CaMK II and MAPK/ERK pdf
... in intracellular Ca 2+ levels are involved in the action of neokyotorphin in L929 fibroblasts. Protein kinases involved in the action of neokyotorphin To study the involvement of non-MAPK protein ... [43 ]. B-Raf plays a major role in embryogenesis [44 ], hematopoiesis [45 ] and normal cell physiology, e.g. in murine embryonic fibroblasts it maintains higher basal level of phosp...
Ngày tải lên: 07/03/2014, 11:20
Báo cáo khoa học: Three novel carp CXC chemokines are expressed early in ontogeny and at nonimmune sites ppt
... 50.7 48 .0 43 .2 44 .2 100* Chicken CXCL12 42 .9 45 .1 44 .0 42 .9 75.3* 100 Human CXCL12 43 .2 45 .7 44 .0 46 .2 65.2* 73.0 100à Mouse CXCL12 41 .8 47 .3 44 .0 48 .4 66.3* 75.3 93.3à 100à Cow CXCL12 45 .1 49 .5 ... are as in Fig. 4. Carp CXCL 14 Zebrafish CXCL 14 Chicken CXCL 14 Human CXCL 14 Mouse CXCL 14 Pig CXCL 14 Carp CXCL 14 100 Zebrafish CXCL 14 94. 0 10...
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx
... protein (summarized in Fig. 7). All truncated HNF1b proteins retaining t he DNA binding domain (e.g. Y352insA) as well as a HNF1b mutant with an in- frame internal deletion in the POU S domain (R137–K161) ... that destroys DNA binding resulted in a r eduction in pronephric size. In contrast, all truncated HNF1b proteins with impaired DNA binding (e.g. A263insGG and E101X) resulte...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states – an unusual flavodoxin pot
... flavin moiety is sandwiched between Trp 74 on one face and the side chain of Thr42 and the main chain atoms of residues 42 44 on the other (Fig. 2A). The isoalloxazine ring is completely buried and ... 1787, 144 – 1 54. 40 Massey V (19 94) Activation of molecular oxygen by flavins and flavoproteins. J Biol Chem 269, 2 245 9– 2 246 2. 41 Lindqvist Y & Bra ¨ nde ´ n CI (1989) The a...
Ngày tải lên: 29/03/2014, 21:20
Báo cáo khoa học: Integrin receptor specificity for human red cell ICAM-4 ligand doc
... of ICAM -4, w e h ave identified critical amino acids involved in the binding s ites of a IIb b 3 4 and a V b 3 integrins, and s hown b y synthetic peptide inhibition that ICAM -4 b 3 integrin inter- actions ... ICAM -4 for a IIb b 3 *anda V b binding, p robably forming a cleft for ligand binding. Binding sites involving two consecutive IgSF domains were already observed in other Ig...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... three N-terminal do- mains, I–III, of ErbB-1 possess the binding sites specific for EGF. In contrast, the replacement of domain III and of domains III and II, resulting in 1 144 -4 and 144 4 -4, respectively, ... chimeric receptors that have the ErbB-1 cytoplasmic region in common (44 44- 1, 44 41-1, 44 11-1, and 41 11-1), the entire extracellular region of ErbB-1 or portion...
Ngày tải lên: 24/03/2014, 03:21
Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... gefitinib or erlotinib in intestinal epithelial cells [53]. Furthermore, the expression of cIAP-1 and of X-linked IAP is reduced by AG 147 8 in squamous cell carcinoma cell lines NA and Ca9-22 [ 54] . ... consists of p15 INK4b , p16 INK4a , p18 INK4c and p19 INK4d . AG 147 8, which, like gefitinib and erlotinib, acts as a specific inhibitor of the EGFR tyrosine kinase, has been...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... present in the PDZ binding motifs of other membrane proteins [17]. We also found interac- tion of PDZ domains 1 + 2 with ORs showing no classical PDZ binding motifs, indicating that the understanding ... indistinguishable in cells over-expressing PDZ domains 1 + 2 (4. 87 ± 0.2 s) compared to control cells (4. 71 ± 0.69 s) (Fig. 5C). In summary, when the interaction between MUPP1 and O...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
... that PF -4 acts via heparin-binding independent interactions. Here, we compared the effects of PF -4 on the s ignalling events involved in the proliferation i nduced by VEGF 165 , which binds heparin, and ... chemokines bind and activate different chemokine receptor isoforms [48 –50], and it would be valuable to determine which bind PF -4 and are expressed in HUVEC. S tudies o...
Ngày tải lên: 19/02/2014, 16:20