... cells interact with twotypes of collagen I found in vivo, and the form of thecollagen determines the cells synthesis and activation of MMP-2 as well as the synthesis of MT1-MMP and TIMP-1.Previously, ... investigates the effect of cell–collagen I interactions on the syn-thesis and activation of MMP-2, as well as synthesis of MT1-MMP and TIMP-1, by using an in vitro model with 3D fibrillar and 2D monomericcollagen. ... expression of MT1-MMP, TIMP-1 and MMP-2 atboth the mRNA and protein levels, in addition to adecreased amount of activated MMP-2 [13,14]. MMPs and TIMPs are associated with cell invasion and metastasis,...