... (marked bold), lands the system into the oscillatory domain, whereas, with a furtherincrease in the stimulus, a single steady state regainsstability. The remaining curves in Fig. 5B (red and green) ... conformation, the SH2 domain binds to pYion the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linkerbetween the SH2 and kinase domains at the back of the small lobe, preventing ... cycle) and a stablesteady state implies subcritical Hopf bifurcation and the appearance of an unstable limit cycle. The unstable and stable limit cycles collide and annihilate in a global bifurcation...