báo cáo hóa học: " Clinical usefulness of the screen for cognitive impairment in psychiatry (SCIP-S) scale in patients with type I bipolar disorder" doc
Báo cáo Y học: Functional studies of the Synechocystis phycobilisomes organization by high performance liquid chromatography on line with a mass spectrometer docx
... biliproteins, either with or without attached linkers, are obtained [6]. The relative stability of biliprotein- linker complexes varies among the biliproteins f rom differ- ent sources. Information ... than the s ingle bilin of the other b ilinproteins and probably react with atmospheric oxygen forming toxic radicals. The protein backbone is, in fact, protected from damage...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
... fluorescent protein; PI, propidium iodide; RAE, arginine-alanine- glutamine; RGD, arginine-glycine-asparagine; STS, staurosporine streptomyces; TIMP, tissue inhibitor of matrix metalloproteinase; YFP, yellow ... In addition, the RGD motif of DP9 was replaced with Arg-Ala-Glu (RAE) to investigate whether this integrin-binding motif played a role. The RGD integrin-binding motif was fi...
Ngày tải lên: 23/03/2014, 11:20
Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... Biol Ther 2003; 2: 491-9. 16. Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in ... activity of RIZ1. In vitro studies showed that PR interacted with a PRB (PR-binding) motif located in the C-terminal region of both RIZ1 and RIZ2, implicating the Yin-Yan...
Ngày tải lên: 25/10/2012, 11:15
Báo cáo y học: " Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU) in a porcine model"
... for the ablation of the pan- cr e a s in a swine model. Our results provide evidence supporting the clinical application of HIFU in patients with pancreatic cancer. Conflict of Interest The ... medical intervention of the pancreatic diseases. A previous preclinical in vivo study in swine demonstrated the feasibility and safety of H I FU for panc...
Ngày tải lên: 25/10/2012, 11:18
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... counted the interactions, we excluded all residues involved in the binding of the metal cofactor. ApeSODs in different forms were superimposed with the least square fit of Ca atoms of the residues in ... Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Japan 5 Power Train...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... incorpo- ration of iron into R2F in vivo, even in the absence of manganese, and it is the availability of manganese that is the limiting factor determining the amount of func- tional metalloradical cofactor ... difference in the reaction mechanism of this RNR and that of other class 1 RNRs or, instead, is a result of the interaction of the R2F with the...
Ngày tải lên: 15/02/2014, 01:20
Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf
... role in stabiliz- ing the dimeric structure, as in CgAKb. Monomer–dimer equilibrium In CgAKb, Thr binding induces the dimerization of CgAKb [20]. Thr is bound at an effector-binding unit formed ... to the inhibitory complex of EcAKIII bound to Lys. Although EcAKIII binds the effector, Lys, at the binding unit formed between ACT1 domains from different chains, MjAK binds Th...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx
... glycoproteins. This response initiates signaling pathways leading to the induction of protective cellular genes, including type- I interferons [initially interferon (IFN)-b, and then IFN- a] and proinflammatory ... and function of the hepatitis C virus NS3-NS4A serine proteinase. Curr Top Microbiol Immunol 242, 149–169. 56 Cheng G, Zhong J & Chisari FV (2006) Inhibition of dsR...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction docx
... reaction is not the limiting step (binding is slower), but in terms of decreasing the amount of substrate that dissociates from the ribozyme before reactivity, effectively increasing the yield of the reaction. Experimental ... end point of 70–80%. Over the period of 15–60 min, this end point does not change, indicating that either an internal equilibrium Table 1. Kinet...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... a 1 -antichymotrypsin and heparin cofactor II contain leucine instead of arginine as P1 residues, which explains why the forma- tion of a stable inhibitory complexes of these serpins is not possible with DESC1 [6]. ... reveals that the most similar regions of these proteinases medi- ate interaction of the two b-barrels, formation of the catalytic machinery and structures...
Ngày tải lên: 19/02/2014, 00:20