báo cáo hóa học: " Mapping SF-36 onto the EQ-5D index: how reliable is the relationship?" pptx

... domain, the overall layout of chorismate and prephenate processing sites in the T-protein resembled that of the P-protein. However, results from the present study showed that the organization of the ... prephenate dehydrogenase. The final step in the biosynthesis of tyrosine in Escherichia coli and other enteric bacteria is the transamination of p-hydroxyphenylpyruvate, whi...

Ngày tải lên: 31/03/2014, 07:20

... of X-rays. This term defines the level of detail, or the minimum distance between structural features that can be distinguished in the electron-density maps. The higher the resolution, that is, the smaller ... part of the protein is rather doubtful. (e) The distances between the ion and the coordi- nating atoms are shown with four decimal digit precision, vastly exceedin...

Ngày tải lên: 16/03/2014, 06:20

... supports this conclusion. The other antibodies in this assay did not hinder the interaction of TC with Cbl at all (Table 3) and therefore we cannot draw any conclusions on the involvement of the other ... transcobalamin. The N- and C-termini are indicated by the corresponding letters (N-terminus is hidden behind the a helix). The colors of different regions correspond to th...

Ngày tải lên: 20/02/2014, 01:20

... noncovalently with the active site of the proteinase [1]. In the locking step that follows, the P 1 – P 1 ¢ bond is cleaved [2,3] and the P 1 residue is coupled to the active site serine of the proteinase ... Relative to (A) the structure shown in (B) is turned approximately 180° around the y-axis and approximately 45° around the x-axis of the coordinate system sho...

Ngày tải lên: 20/02/2014, 11:20

... protease-resistant isoform of the prion protein in brains of individuals with these diseases. This abnormal form of the protein (PrP Sc ) is also suggested to be the infectious agent in the disease on the ... PrP c could be in the femtomolar range [18]. Despite these inconsistencies, the conclusion that PrP c is a Cu-binding protein is widely accepted. The implication of...

Ngày tải lên: 21/02/2014, 00:20

... throughout the body. Their expressions are tissue-specific, but in disease states such as cys- tic fibrosis, inflammation and cancer, this specificity can be disturbed. MUC5AC is normally expressed in the ... loaded is shown by the reactivity of the mAb against myc. One reason for the requirement of the N-terminal 91 amino acids could be that these are necessary for the correct...

Ngày tải lên: 07/03/2014, 05:20

... were positioned within the catalytic domain of the enzyme. The role of the particular oxygen atoms of the selected phosphate groups is also discussed. Moreover, we ana- lyzed the function of the oxygen moiety ... in the concentration of metal ions present in the catalysis reaction, and the k Mn obs value for this mutant enzyme was three-fold higher than the k Mn obs va...

Ngày tải lên: 07/03/2014, 10:20

... interaction. In all plots, the arrow on the left indicates the beginning of the associ- ation phase; the beginning of the dissociation phase is marked by the arrow on the right. Interaction site ... (HBS). Discussion In cyanobacteria, it has previously been shown that the disulfide bridge on the N-terminal part of CP12 is involved in binding PRK, whereas the C-termina...

Ngày tải lên: 16/03/2014, 13:20

... a role in the enzyme’s mechanism of action. The data pre- sented here show that the glutarate part of inhibitor is essential for the affinity to the GCPII, whereas the S1 pocket of the enzyme ... such that the orientation and binding of the glutamate residue is identical to the crystal structure of the rhGCPII ⁄ glutamate complex, and the N-acetyl-l-aspartate part o...

Ngày tải lên: 23/03/2014, 07:20

... recognized by the activated a IIb b 3 integrin. Therefore, in the context of this study, the fine mapping of the fibrinogen-binding domains on the a IIb subunit was accomplished and their potential role ... peptide synthesis (SPPS) [29– 31]. A spare glycine was incorporated as the C-terminal residue (shown in parenthesis in the peptide sequences below) to simplify and reduce th...

Ngày tải lên: 31/03/2014, 07:20