báo cáo hóa học: " Health-related quality of life in young adults with symptoms of constipation continuing from childhood into adulthood" potx
Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... [8,9]. BTB ⁄ POZ proteins are often transcriptional regulators containing a C 2 H 2 domain for DNA binding, but can also be found in combination with various other protein–protein inter- action motifs, ... a working model in which they bind to ERF ⁄ AP2s, potentially interfering with their DNA-binding ability, but which ultimately results in the degradation of ERF ⁄ AP2 proteins (...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc
... resulting in elucidation of a new activity of sili- catein as a silica esterase, we used recombinant silica- tein-a from the demosponge S. domuncula [10]. Results Presence of silicatein in the ... the spicules in concentric rings (Fig. 2B). A closer view of the axial canal in the center of the spicule reveals local- ization of silicatein in the axial filament as well as...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... pretreated with the PKA inhibitors, KT5720 and H89 [28]. Following saponin permeabilization, this resulted in increased InsP 3 -induced Ca 2+ release with either inhibitor, with an EC 50 of 1 lm ... (B) Initial part of the same thrombin generation curves. (C) Bars indicate the effects of preincubation on initial rates (5 min) of thrombin generation (n = 3–5). (D) Human platele...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx
... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate ... kinetic properties of the recombinant AADH were indistinguishable from those of the native enzyme isolated from A. faecalis. TTQ biogenesis in recombinant AADH is functional despit...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... formation. Incubation of Cys124 peptide with BB1 indeed resulted in a 35% inhibition of amyloid fibril formation. Our results are in keeping with the clinical observations of Arg124 mutation-linked amyloidosis ... for integrins. The particular integrins with binding capacities for the corneal TGFBI protein remain to be fully identified. Kim et al. [3] have recently shown that al...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo khoa học: Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx
... residue (Trp677 in rat, Trp676 in human CPR) stacks against the isoalloxa- zine ring of the FAD cofactor thereby preventing hydride transfer from NADPH to the flavin-N5 and thus necessitating a potentially ... transfer during the stoichiometric reduction of CPR with NADPH. Summary of results Scheme 2 outlines possible reasons for the diminishing intermediate formation of blue d...
Ngày tải lên: 07/03/2014, 06:20
Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx
... the sulfuration of the C-terminal glycine in ThiS and MoaD, involved in thiamine biosynthesis and molyb- dopterin biosynthesis, respectively, and for the sulfura- tion of uridine in tRNA to thiouridine can ... containing N-methylhistidine, 5-methyl- arginine or 2-methylglutamine The methylated histidine (H257) was found in the a-sub- unit of MCRs from all methanogenic archaea...
Ngày tải lên: 16/03/2014, 05:20
Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf
... separately fitting domains I and II to the structure of DcP. The identification of the appropriate clipping points was aided by using the Alternate Domain Fit tool from the suite of tools within the swiss-pdbviewer ... impli- cated in substrate binding, are shown in Fig. 3 to be within hydrogen bonding distance from the substrate. As energy minimization only allows for limited con...
Ngày tải lên: 23/03/2014, 06:20
Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
... with 10% fetal bovine serum (Fig. 5D) followed by staining with Oil Red O showed a significant increase in lipid droplets in comparison with Ad.CMV.GFP-infected cells (Fig. 5C). In agreement with ... and then with a solution of 50 mm NH 4 Cl in NaCl ⁄ P i . Slides were washed with NaCl ⁄ P i and incubated in NaCl ⁄ P i containing 5% BSA for 30 min. For immunostaining, t...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo y học: "Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams"
... promotes tracking effects over time, integrating detailed process knowledge into the work of interpretation, using small samples and short experi- mental cycles of change, and using multifactorial ... examples of before-and-after studies dealing with single-centre data [52-56]. Inherent within this type of evidence is the lack of rigour and generalisability. Furthermore, the mag...
Ngày tải lên: 25/10/2012, 10:35