... different domain of the E gene of DENV-3. Domain III and domain I were under the influ- ence of positive selection (d N /d S :21.52, 2.45) and domain II was under the influence of neutral selection ... determine the num- bers of transition and transversion changes, and the mean and proportion of difference, Hamming distance and p- distance, as described previ...
Ngày tải lên: 20/06/2014, 04:20
... conception and design of the study, acquisition of data, interpretation of data, drafting the manuscript, and critical revisions of the manuscript. SK contributed to acquisition of data, and critical ... revisions of the manuscript. PO contributed to acquisition of data, interpretation of data, and critical revisions of the manuscript. DRB contributed...
Ngày tải lên: 20/06/2014, 08:20
báo cáo hóa học: " Development of the Knee Quality of Life (KQoL-26) 26-item questionnaire: data quality, reliability, validity and responsiveness" pptx
... Central Page 1 of 11 (page number not for citation purposes) Health and Quality of Life Outcomes Open Access Research Development of the Knee Quality of Life (KQoL-26) 26-item questionnaire: data quality, ... measures of health and quality of life [2]. Only three of the five instruments that incorporate the views of patients have been adeq...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... 0.05). Discussion The present work shows the use of the regulatory sequences of the H19 gene for the development of DNA- based therapy for human ovarian cancer related ascites. The successful development of ... μg of Luc -H19 or the LucSV40 plasmid. The values represent the luciferase activity of the H19 promoter relative to the activity of the contr...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... cells [16-18]. The activities of IL21 have been shown to be highly dependent on the lineage of the target cell, the activation state of the target cell and the presence of other co-stimulators and immune ... analyzed the data and co-wrote the manuscript. SJ and AAW performed all the pilot studies in humans and monkeys that identified the candidate bioma...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... ISH and the expression levels of IGF2-P4 and H19 transcripts were determined by the intensity of the hybridization signal and by the quantity of the stained cells. Table 3 shows that out of 28 ... early studies of our group and others, the transcriptional regulatory sequences of the H19 and IGF2 genes emerged as candidates for cancer targe ted therapy. H19...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " Development and psychometric assessment of the COPD and Asthma Sleep Impact Scale (CASIS)" pdf
... levels of impaired activities, symptoms, and poorer quality of life for the COPD sample and greater levels of impaired activities, symptoms, social function- ing, and poorer quality of life scores ... measures and extend our understanding of the impact of respiratory disease symptoms on sleep impact and quality. Given the prevalence of sleep problems in...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight)" pdf
... and known group validity were also met with the exception of the domain of Daily Life (proven in an ad hoc analysis) as well as the 1/2 standard deviation threshold for the MID. Conclusion: The ... generation in the development of two obesity-specific measures: the Obesity and Weight Loss Quality of Life (OWLQOL) Questionnaire and the Weight-Related Sym...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... A measure of health-related quality of life and quality of life for patients with pulmonary hypertension. Qual Life Res 2006, 15:103-15. 16. Rasch G: On general laws and the meaning of measurementin psychology. ... manuscript. JB designed and managed the valu- ation survey, analysed and reported on the valuation data and contributed to the writing of t...
Ngày tải lên: 18/06/2014, 19:20