Báo cáo sinh học: "Protein kinase CK2a is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes" docx

... overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes. Journal of Translational Medicine 2011 9:97. Zou et al. Journal of Translational Medicine ... statistically significant. Results CK2a is overexpressed in colorectal cancer CK2a protein expression was analyzed in 144 patients (104 with CRC...

Ngày tải lên: 18/06/2014, 19:20

... potential metastasis suppressor gene missing in metastatic bladder carcino ma cell lines [2] and subse- quently investigated in some types of cancer. In prostate cancer and breast cancer, expression ... actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. J Biol Chem 2004, 279:14929-1493...

Ngày tải lên: 18/06/2014, 19:20

... apoptosis. TCDD induces nPKC kinase activity in L-MAT cells To establish whether TCDD increases nPKC kinase activity, we examined nPKC kinase activity by using PKCh pseudo-substrate, which is preferentially ... L-MAT cell apoptosis is induced by TCDD, and the failure of actinomycin D (an inhibitor of gene transcription) and cycloheximide (an inhibitor of de novo protein synt...

Ngày tải lên: 23/03/2014, 13:20

... Scagliotti Abstract Background: Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to this fami ly are activated in the G2/M phase of the cell cycle being involved in mitotic ... data analysis and interpretation, acquiring clinical samples, follow-up clinical information and final writing of the manuscript. VM, SS, PC and EB part...

Ngày tải lên: 18/06/2014, 19:20

... used for in vitro kinase assays. In vitro kinase assays Recombinant human protein kinase CK2 holoenzyme (0.5 U, corresponding to 1 ng; New England Biolabs, Frank- furt am Main, Germany) was incubated ... found- ing member of a novel family of atypical protein serine kinases [12–14]. It is essential in yeast and is only distantly related to previously characterized pro- tein...

Ngày tải lên: 18/02/2014, 16:20

... induction and its membrane localization [11]. The PIP 2 binding of PKCe may in uence the function of actin binding proteins, leading to actin rearrange- ment and neurite induction. In addition, the binding ... mice. In this review, we focus on the involvement of protein kinase Ce in neurite outgrowth, presynaptic regula- tion, alcohol actions, ischemic preconditioning and pain....

Ngày tải lên: 23/03/2014, 07:20

... Apoptosis is a well-known pathway in which mitochondria are involved. Protein kinase Ce has been classified as a novel type of protein kinase C and is involved in many cellular events regulating ... comprises the intrinsic pathway, which is triggered by DNA damage. DNA-dependent protein kinase (DNA-PK), which is fundamentally involved in this pathway, is a nuclear ser...

Ngày tải lên: 23/03/2014, 07:20

... u@phy.med.kyoto-u.ac.jp Abbreviations: DAP kinase, death-associated protein kinase; MLC kinase, myosin light chain protein kinase; CaM kinase, Ca 2+ /cal- modulin-dependent protein kinase; ZIP kinase, zipper-interacting protein ... involved in ceramide- induced apoptosis, and that the intrinsic DAP kinase activity is critical for ceramide-induced apoptosis. Keywords: apoptosis;...

Ngày tải lên: 24/03/2014, 00:21

... pharmacist, one database operator and six PLWHAs – two involved in counselling, two in keeping files and guiding patients to the doctors, and two in organizing home visits of irregular and defaulter ... was 348 minutes with the data observed in 2004, and 264 minutes with the 2005 data. Of this total reduction of 84 minutes, 54 minutes is due to a decrease in number of vi...

Ngày tải lên: 18/06/2014, 17:20