... Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland, 3Division of Hematology and Transplant, Department of Clinical Medicine and Immunological Sciences, University of Siena, ... progression, also as aconsequence of microenvironmental interactions (i.e. sec-ondary genetic lesions). Telomer lenght too was includedin this chapter, although often consequence of environ-mental ... pathogenesis and the clinicobiologicalfeatures of CLL in relationship of these factors, is also provided.IntroductionB-cell chronic lymphocytic leukemia (CLL) is a mono-clonal expansion of small...