... approaches for introducingIL2 into the tumor environment include injection of thecytokine intratumorally [17] and administering intratu-moral injections of adenovirus encoding IL2 [18]. In thelater ... demonstrated byincreases in serum levels of sIL2R, IL10, and neopterin. There was evidence of increased tumor infiltrationby T cells, but not NK cells, in most post-dosing biopsies, suggesting recruitment ... there were ≥ 50% of cells with 1+ or greaterstaining intensity (GD2, S100, or HLA-A), or ≥ 1.0 cellsper high power field (cell/ HPF). In addition, the relativeintensity of staining (0, 1+, 2+,...