báo cáo hóa học: " Assessing the empirical validity of alternative multi-attribute utility measures in the maternity context" potx
Báo cáo hóa học: " Reliability and construct validity of the Participation in Life Activities Scale for children and adolescents with asthma: an instrument evaluation study" docx
... each of the three indicators before summing the indicator scoresFigure 1Scoring of the Participation in Life Activities Scale is completed by computing the mean scores for each of the three indicators ... from the child was obtained prior to data col-lection.Power analysis In determining sample size for psychometric testing, the number of items contained in the target instrument, sen-sitivity of ... advertising the studies wereoffered to families through physicians' offices andschools. Families interested in learning about the studycontacted the PI. After being informed of the purpose...
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Tài liệu Báo cáo Y học: Antibacterial and antifungal properties of a-helical, cationic peptides in the venom of scorpions from southern Africa pptx
... Gram-negative bacteria, enabling the disruption of the outermembrane and facilitating the interaction of the toxin with the inner membrane. In the presence of high Mg2+ions, the MIC of compounds that ... that there is a high conservation in aminoacid sequence of the peptides in the venom of scorpionsbelonging to the same family, independent of the continentand region where they live. In this ... for the growth inhibiting effect of the peptides. Experiments with melittin and mastoparan gave the same results. The role of LPS in the interaction was alsodemonstrated by the lack of effect of...
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Báo cáo khoa học: Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase pdf
... around which the short a-heli-cal LID domain, situated in the C-terminal moiety,and the NMP-binding (NMPbind) domain move in aninduced-fit mechanism, closing upon binding of the phosphate ... further explore the contribution of theseamino acids interacting with the pyrimidine ring to the catalysis of E. coli CMP kinase. Substitution of the side chain from a well-structured protein ... the loss of the self energy in the wild-type enzyme of the residue that was mutated,DGpairwisei;jðWTÞ are the pair wise energies of the original resi-due ‘i’ in the native protein with the...
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Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
... signaling in the hypodermis regulates whole animal fluid balance[10]. The intestine of adult C. elegans is comprised of 20epithelial cells that function in digestion and nutrientabsorption. In ... refolding of misfoldedproteins. Loss of function of protein homeo-stasis genes also causes accumulation of damaged proteins and activation of gpdh-1expression. Green arrows and red lines indi-cate ... facilitates the study of biological processes andhas made it possible to trace the lineage of every adultcell beginning with the first cell division.C. elegans inhabits surface soil and decaying organicmatter...
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Báo cáo hóa học: " S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)" potx
... levels of the g-globin gene promoter. The level of DNA methylation of 5 CpG sites within the g-globin promoter was determined by bisulfite sequenceanalysis. S110 induced DNA hypomethylation of theseCpG ... pharmacokinetic analysis, with the remaining nine injections administered by subc uta-neous injection on the subsequent days. Bone marrow(BM) aspirations from the hips were performed follow-ing the ... methylation of the g-globin gene promoter region in culturedhuman erythroid progenitor cells. The effects of decitabine and S110 on the DNA methylation of 5 CpG sites located within the 5’ g-globinpromoter...
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báo cáo hóa học: " Assessing the empirical validity of alternative multi-attribute utility measures in the maternity context" potx
... empirical validity of multi-attribute utility measures has involved examin-ing whether the utility scores generated by the measures reproduce hypothesised differences between groups of individuals ... assessed the empirical validity of multi-attribute utility measures in the maternity context. The objective of this study was to compare the empirical valid-ity of EQ-5D versus SF-6D utility ... properties of these measures in the maternity context. The studyreported in this paper investigated the utility scoresderived from two multi-attribute utility measures cur-rently in wide use,...
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báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx
... purposes)Journal of Translational MedicineOpen AccessResearch Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patientsJessie ... receptor; (IGFBP-3): Insulin-like GrowthFactor Binding Protein-3; (IGFBP-4): Insulin-like GrowthFactor Binding; Protein-4; (MAPK): Mitogen-activatedprotein kinase; (IMCG): Interdisciplinary MelanomaCooperative ... or tyrosine kinase inhibitors. Several of these drugs are currently in Phase I trials as single agentsor in combination with chemotherapy. [7-11] A criticalaspect in the design of these trials...
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báo cáo hóa học: " Development and psychometric validation of a self-administered questionnaire assessing the acceptance of influenza vaccination: the Vaccinees'''' Perception of Injection (VAPI©) questionnaire" docx
... years, intramuscular (IM) vaccination of inactivated influenza vaccine has formed the cornerstone of seasonal influenza prevention. The intradermal (ID)route of administration is an interesting alternative ... subjects gave their writteninformed consent before being included in the clinicalstudies and received ID or IM vaccine according to the ran-domisation at inclusion. The initial version of the VAPIquestionnaire ... constituted of two-thirds of the UK clinical trial subjects. The scalestructure was then validated in the remaining one-third of the "UK validation population", to assess the robustness of the...
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báo cáo hóa học:" Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer" pdf
... collected at the University of Pennsylvania or the University of Michigan. After obtain-ing informed patient consent, ascites was collected eitherintraoperatively or at the time of therapeutic ... purposes)Confirmation of activity of the murine anti-CD52 immunotoxinFigure 5Confirmation of activity of the murine anti-CD52 immunotoxin. A (1) FACS analysis of CD14+ and CD3+ cells in peripheral ... be minimized by intraperitoneal delivery of the drug.Despite being a well-documented therapeutic target, the exact function of CD52 remains unknown. In the ID8-VEGF tumors, VLC account for the...
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báo cáo hóa học:" High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis" potx
... D. The amounts of ascites werequantified by recording weights of each mouse. The weights of Groups A-C were maintained at about 20 g butGroups D-G increased beginning 6 days after cancer injec-tion ... of 100 mm in diameter, and then 5 × 105 cells in 200 ml PBSwere injected into the abdominal cavities of experimentalmice using a 21 G injector. The high dose ascorbic aciddose of 1.7 × 10-4 ... were included in each experiment. Each datapoint represents the average of three experiments and the error bars indicate the standard deviation of individualexperiments unless mentioned otherwise.Hematoxylin-eosin...
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