... an interac-tion of PrPCwith accessory proteins, such as trans-membrane proteins involved in PrP-induced signaling.Alternatively, deletion of the HD could indirectlyaffect intermolecular interactions ... isoform of prion protein is not exactly known,the impact of gain of toxic function or loss of function, or a combination of both, in prion pathology is still controversial. There is increasing ... theneurotoxic properties of PrPDF. The internal HD wasidentified as an important domain for basolateral sort-ing of PrPC. Moreover, Dpl, containing either thewhole N-terminal domain of PrPCor the...