Báo cáo sinh học: " HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system" doc

... the ubiquitin/ proteasome system (UPS) in the above activity of Vpr. We report that the general function of the UPS is required for Vpr to induce G 2 checkpoint activation, as incubation of Vpr- expressing ... Central Page 1 of 8 (page number not for citation purposes) Virology Journal Open Access Research HIV-1 Vpr activates the G 2 checkpoint through m...

Ngày tải lên: 18/06/2014, 18:20

... the ubiquitin/ proteasome system (UPS) in the above activity of Vpr. We report that the general function of the UPS is required for Vpr to induce G 2 checkpoint activation, as incubation of Vpr- expressing ... citation purposes) Virology Journal Open Access Research HIV-1 Vpr activates the G 2 checkpoint through manipulation of the ubiquitin protea...

Ngày tải lên: 20/06/2014, 01:20

... confirm the growing recognition of the importance of PHC. It was the main subject of the 2008 WHO World Hea lth Report, has the endorsement of WHO Director-General Margaret Chan [5], and was the ... topic of a themed issue of the Lancet [6]. Sub-Saharan Africa has only 3% of the global health workforce [7] but accounts for almost half o f the 7.7 million child...

Ngày tải lên: 18/06/2014, 17:20

... from the quality assurance portion of the evaluation were used to calculate error rates at the level of the facility and of the province. Since these errors were also tallied according to the ... evaluation as well as to record the number of clients seeking services and their basic demographics. The stand- ardization of these logs allowed for the generation of a...

Ngày tải lên: 18/06/2014, 17:20

... committees and in the implementation of community health programmes. One of the major gaps repeatedly identified by public health experts in the capacity of public health officials is the lack of experience ... technical knowledge of participants and provide them with a variety of options that can be imme- diately put into practice within their work-environment roles. The...

Ngày tải lên: 18/06/2014, 17:20

... investigated the ef fect of RVL on the microvascular phase of the hepatic metastasis process of B16M cells. First, the effects of RVL on the capillary arrest and early metastatic growth of intrasplenically- injected ... by SPPS statistical software for Microsoft Windows, release 6.0 (Professional Statistic, Chicago, IL). Homogeneity of the variance was tested using th...

Ngày tải lên: 18/06/2014, 19:20

... presenting the pulse of Src activity in the plane of the inactive and active fractions, s i and s 1 . If the duration of the stimulus exceeds the critical value, the trajectory in the (s i , ... steady states of the Src cycle. When there are three intersections, the steady state O 1 at the lower branch of the Z-shaped curve (i.e. low Src activity) and the s...

Ngày tải lên: 18/02/2014, 11:20

... [41]. The use of thrombin significantly increases the cost of the purification, and the require- ment for HPLC increases the length and complexity of the purification procedure. Moreover, as with the studies ... concentrated manner at the top of the column, or, if bound to the resin prior to packing the column, the salt gradient concen- trates the peptide on its...

Ngày tải lên: 18/02/2014, 13:20

... 5A,B). Loss of the LBD abolished the ability of C-Vrp1p 364)817 to restore growth of vrp1D cells at elevated temperature. We next assessed the importance of the LBD for the ability of C-Vrp1p 364)817 to ... relative expression level of the GFP-tagged proteins is indicative of that of the equivalent untagged proteins. Lipid anchoring of C-Vrp1p bypasses the re...

Ngày tải lên: 18/02/2014, 16:20

... encoded another type of KLK11, isoform 2, despite the presence of exon 1c. The secretory path- ways of KLK11 isoforms appeared to differ, although both isoforms were secreted from cells. Hence, the ... part of isoform 2 mRNA. The third exon, exon 1c, extended from +1379 to +1454. The noncoding exons of exons 1a and 1c contributed to the 5¢ nontranslated region of isofo...

Ngày tải lên: 19/02/2014, 06:20